| 余红璐,张 莉,汪朦朦,丰小敏,付 强,江 馨,熊莉娜.结直肠癌组织LASS2、HOXB7蛋白表达与凋亡指数及预后的关系分析[J].,2021,(17):3383-3387 |
| 结直肠癌组织LASS2、HOXB7蛋白表达与凋亡指数及预后的关系分析 |
| Expression of LASS2 and HOXB7 in Colorectal Cancer and its Relationship With Apoptosis Index and Prognosis |
| 投稿时间：2021-03-30 修订日期：2021-04-26 |
| DOI：10.13241/j.cnki.pmb.2021.17.039 |
| 中文关键词: 结直肠癌 LASS2 HOXB7 预后 淋巴结转移 凋亡指数 |
| 英文关键词: Colorectal cancer LASS2 HOXB7 Prognosis Lymph node metastasis Apoptosis index |
| 基金项目:国家自然科学基金项目（81974381） |
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| 中文摘要: |
| 摘要 目的：探讨结直肠癌（CRC）组织人源长寿保障基因2（LASS2）、同源异型盒基因B7（HOXB7）表达与凋亡指数（AI）及预后的关系。方法：选择2013年10月至2015年4月期间在我院接受治疗的105例CRC患者作为研究对象。检测其CRC组织以及癌旁组织中LASS2、HOXB7表达以及AI，分析LASS2、HOXB7表达与临床病理特征的关系，采用Kaplan-Meier生存曲线分析不同LASS2、HOXB7表达患者总生存率的差异，Cox比例风险回归分析CRC患者预后的影响因素。结果：CRC组织中LASS2阳性率低于癌旁正常组织，而HOXB7阳性率高于癌旁正常组织（P<0.05），CRC组织中AI低于癌旁正常组织（P<0.05）。经Spreaman相关性分析显示CRC组织LASS2阳性率和AI呈正相关关系，而HOXB7阳性率和AI呈负相关关系（P＜0.05）。LASS2表达与临床分期、浸润深度和淋巴结转移有关（P<0.05），而HOXB7表达与临床分期和淋巴结转移有关（P<0.05）。HOXB7表达阳性患者的生存率低于HOXB7表达阴性患者，而LASS2表达阳性患者的生存率高于LASS2表达阴性患者（P<0.05）。Cox比例风险回归分析结果显示，临床分期为Ⅲ期、有淋巴结转移、LASS2阴性表达、HOXB7阳性表达以及AI＜2.0%均是影响CRC患者预后的危险因素（P<0.05）。结论：在CRC组织中HOXB7阳性率升高，而LASS2阳性率以及AI下降，且与临床分期以及淋巴结转移密切相关。LASS2、HOXB7表达及AI与CRC患者的生存和预后联系密切。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of human longevity guarantee gene 2 (LASS2) and homologous box gene B7 (HOXB7) and apoptosis index (AI) and prognosis in colorectal cancer (CRC) tissues. Methods: A total of 105 patients with CRC who received treatment in our hospital from October 2013 to April 2015 were selected as subjects. The expressions of LASS2 and HOXB7 and AI in CRC tissues and adjacent tissues were detected, and the relationship between the expressions of LASS2 and HOXB7 and clinicopathological characteristics was analyzed. Kaplan-Meier survival curve was used to analyze the differences in overall survival of patients with different expressions of LASS2 and HOXB7. Cox proportional risk regression analysis of prognostic factors in CRC patients. Results: The positive rate of LASS2 in CRC tissues was lower than that in adjacent normal tissues, while the positive rate of HOXB7 was higher than that in adjacent normal tissues(P<0.05). The AI in CRC tissues was lower than that in adjacent normal tissues(P<0.05). Spreaman correlation analysis showed that the positive rate of LASS2 was positively correlated with AI, while the positive rate of HOXB7 was negatively correlated with AI(P<0.05). The expression of LASS2 was correlated with clinical stage, invasion depth and lymph node metastasis(P<0.05), while the expression of HOXB7 was correlated with clinical stage and lymph node metastasis (P<0.05). The survival rate of HOXB7 positive patients was lower than that of HOXB7 negative patients, while the survival rate of LASS2 positive patients was higher than that of LASS2 negative patients (P<0.05). Cox proportional risk regression analysis showed that clinical was stage Ⅲ, lymph node metastasis, negative expression of LASS2, positive expression of HOXB7 and AI＜2.0% were all risk factors affecting the prognosis of CRC patients(P<0.05). Conclusion: The positive rate of HOXB7 is increased in CRC tissues, while the positive rate of LASS2 and AI are decreased, which are closely related to clinical staging and lymph node metastasis. The expression of LASS2, HOXB7 and AI are closely related to the survival and prognosis of CRC patients. |
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