| 秦 龙,李 婷,任明扬,罗彬予,钟 扬,何 苗.围手术期应用ω-3多不饱和脂肪酸对胃癌根治术患者术后恢复及生活质量的影响[J].,2019,19(2):346-349 |
| 围手术期应用ω-3多不饱和脂肪酸对胃癌根治术患者术后恢复及生活质量的影响 |
| Effect of ω-3 Polyunsaturated Fatty Acids on Postoperative Recovery and Quality of Life in Patients with Radical Gastrectomy duringthe Perioperative Period |
| 投稿时间：2018-06-17 修订日期：2018-07-12 |
| DOI：10.13241/j.cnki.pmb.2019.02.032 |
| 中文关键词: 胃癌根治术 ω-3多不饱和脂肪酸 免疫功能 营养 生活质量 |
| 英文关键词: Radical gastrectomy for gastric cancer ω -3 polyunsaturated fatty acids Immune function Nutrition Life quality |
| 基金项目:四川省科技厅基金项目（2013YJ0389） |
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| 中文摘要: |
| 摘要 目的： 探讨围手术期应用ω-3多不饱和脂肪酸对胃癌根治术患者术后恢复及生活质量的影响。方法：选择2015年1月~2016年12月期间南充市中心医院收治并行胃癌根治术的胃癌患者100例，按照随机数字表法分为对照组和观察组，每组50例。对照组接受常规静脉营养支持治疗，观察组在此基础上接受ω-3多不饱和脂肪酸治疗。检测并比较两组患者术前、术后1d、术后2周血清视黄醇结合蛋白（RBP）、前白蛋白（PA）、白蛋白（ALB）、转铁蛋白（RTF）、CD3+、CD4+、CD8+细胞水平，并于术前、术后2周应用生活质量核心量表（EORTCQ LQ-C30）评价患者生活质量。结果：两组患者术后1d以及对照组术后2周的RBP、PA、ALB、RTF、CD3+、CD4+、CD4+/CD8+均较术前显著降低（P<0.05），而CD8+均较术前显著升高（P<0.05），术后1 d、术后2周观察组RBP、PA、ALB、RTF、CD3+、CD4+、CD4+/CD8+显著高于对照组（P<0.05），而CD8+显著低于对照组（P<0.05）；术后两组患者EORTCQ LQ-C30功能量表各项评分较术前均显著提高，症状量表各项评分较术前显著降低（P<0.05），术后观察组功能量表各项评分显著高于对照组，症状量表各项评分显著低于对照组（P<0.05）。结论：应用ω-3多不饱和脂肪酸能够促进胃癌根治术后患者机体免疫功能的恢复，改善患者的营养状况，提高患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of ω-3 polyunsaturated fatty acids on postoperative recovery and quality of life in patients with radical gastrectomy during the perioperative period. Methods: 100 patients with gastric cancer who underwent radical resec- tion of gastric cancer in nanchong central hospital from January 2015 to December 2016 were randomly divided into observation group and control group with 50 cases in each group. The control group received routine parenteral nutrition support, and the observation group received ω-3 polyunsaturated fatty acid treatment on this basis. The serum retinol binding protein (RBP), prealbumin (PA), albumin (ALB), transferrin (RTF), CD3+, CD4+ and CD8+ were detected and compared before operation and 1 d, 2 w after operation in two groups. The quality of life (QOL) was assessed by life quality core scale (EORTCQ LQ-C30) 2 w after and before operation. Results: 1 d after operation in two groups and 2w after operation in the control group, the RBP, PA, ALB, RTF, CD3+, CD4+ and CD4+/CD8+ were signifi- cantly decreased, and CD8+ was significantly increased. 1d and 2w after operation in the observation group, the RBP, PA, ALB, RTF, CD3+, CD4+ and CD4+/CD8+ were significantly higher than that of the control group (P<0.05), and CD8+ was significantly lower than the control group (P<0.05). The functional EORTCQ LQ-C30 score in two groups was significantly higher than before operation, the symp- tomatic EORTCQ LQ-C30 score was significantly lower than before operation (P<0.05), the The functional EORTCQ LQ-C30 score of observation group was significantly higher than the control group, the symptomatic EORTCQ LQ-C30 score was significantly lower than the control group (P<0.05). Conclusion: The use of ω -3 polyunsaturated fatty acids in the operation of gastric cancer can promote the re- covery of immune function, improve the nutritional status of patients and improve the quality of life of patients. |
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