| 李正龙,李鑫恒,郑汪洋,李景林,王志东,姜兴明,崔云甫.长链非编码RNA HULC与消化系统肿瘤的相关性研究及作用机制*[J].,2019,19(1):193-196 |
| 长链非编码RNA HULC与消化系统肿瘤的相关性研究及作用机制* |
| Research of Relevance and Regulatory Mechanisms of Long Non-coding RNA HULC in Digestive Neoplasms* |
| 投稿时间：2017-12-26 修订日期：2018-01-23 |
| DOI：10.13241/j.cnki.pmb.2019.01.042 |
| 中文关键词: 长链非编码RNA HULC 消化系统肿瘤 调控机制 |
| 英文关键词: Long non-coding RNA Highly up-regulated in liver cancer Digestive neoplasm Regulatory mechanism |
| 基金项目:国家自然科学基金项目（81602088）；黑龙江省卫生计生委科研课题（2016-049）；黑龙江省博士后资助课题（LBH-Z16096）；哈尔滨医科大学创新科学研究基金项目（2016LCZX09） |
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| 中文摘要: |
| 摘要：随着全基因组测序技术的快速发展，越来越多的长链非编码RNA（long noncoding RNA, lncRNA）分子被发现，逐渐成为新的研究热点。LncRNA HULC（highly up-regulated in liver cancer）是一种在肝癌中呈异常上调表达的长链非编码RNA，并参与调控了肝癌细胞增殖、抗凋亡、侵袭及上皮间质化等诸多肿瘤恶性生物学行为。随着研究的不断深入，发现HULC于其他消化系统肿瘤（胃癌、胰腺癌、结肠癌等）中同样呈现上调表达，可通过不同作用机制调控肿瘤的发生发展，并有望成为新型肿瘤诊断标志物和精准分子治疗的靶点。本文就近年来LncRNA HULC与消化系统肿瘤的相关性研究及其作用机制进行综述。 |
| 英文摘要: |
| ABSTRACT: With the rapid development of the whole genome sequencing technology, a growing number of long non-coding RNAs have been discovered and gradually become new research highlights. LncRNA HULC（highly up-regulated in liver cancer）is one of non-coding RNAs that abnormally upregulated in hepatocellular carcinoma while involved in the regulation of various malignant biological behaviors including tumor cell proliferation, anti-apoptosis, invasion and epithelial-mesenchymal transition. With the deepening of the study, HULC was found dysregulated in various digestive neoplasms, including gastric cancer, pancreatic cancer, colorectal cancer and many others, and different molecule mechanisms have been demonstrated to be involved in tumor progression. To sum up, it is expected to become the new biomarker and accurate molecular target of therapy. This review briefly presented the relevance between HULC and digestive neoplasms together with the underlying regulatory mechanisms. |
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