| 杨甫文,陈贤明,张 贤,李建忠,陈 辉.鼻炎患者血清中IL-27、IL-17、IL-10在变应性的表达及临床意义[J].,2018,(1):126-129 |
| 鼻炎患者血清中IL-27、IL-17、IL-10在变应性的表达及临床意义 |
| Expression and Clinical Significance of IL-27, IL-17 and IL-10 in Serum of Patients with Allergic Rhinitis |
| 投稿时间：2017-05-01 修订日期：2017-05-25 |
| DOI：10.13241/j.cnki.pmb.2018.01.028 |
| 中文关键词: 鼻炎 变应性 白细胞介素-17 白细胞介素-10 白细胞介素-27 |
| 英文关键词: Rhinitis Allergic Interleukin-17 Interleukin-10 Interleukin-27 |
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| 中文摘要: |
| 摘要 目的：探讨鼻炎患者血清中白细胞介素-27（IL-27）、白细胞介素-17（IL-17）、白细胞介素-10（IL-10）在变应性中的表达以及临床意义。方法：选取2013年5月到2014年5月我院收治的变应性鼻炎患者60例为研究组，另外选取健康志愿者60例为对照组，应用酶联免疫吸附试验（ELISA）检测入选者血清中的IL-27、IL-17以及IL-10的表达情况，并分析其相关关系。结果：研究组血清中IL-27、IL-10水平显著低于对照组，差异具有统计学意义（P<0.05）；研究组IL-17水平显著高于对照组，差异具有统计学意义（P<0.05）；研究组患者血清中的IL-27和IL-17呈负相关关系（r=-0.372，P=0.035），IL-27和IL-10呈正相关关系（r=0.524，P=0.026），而IL-17和IL-10无相关关系（r=0.519，P=0.318）。结论：变应性鼻炎患者中IL-27和IL-10呈低表达，而IL-17呈高表达，IL-27可能对IL-17和IL-10具有免疫调节的作用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the expression and clinical significance of interleukin-27(IL-27), interleukin-17(IL-17), inter- leukin-10(IL-10)in serum of patients with allergic rhinitis. Methods: A total of 60 patients with allergic rhinitis, who were admitted to Fuzhou General Hospital of PLA from May 2013 to May 2014, were chosen as study group; in addition, 60 healthy volunteers were cho- sen as control group. The expression of IL-27, IL-17 and IL-10 in the serum of the selected subjects were detected by enzyme-linked im- munosorbent assay(ELISA), and the correlation among them was analyzed. Results: The serum levels of IL-27 and IL-10 in the study group were significantly lower than those in the control group, and the difference was statistically significant(P<0.05), and the level of IL-17 in the study group was significantly higher than that in the control group, the difference was statistically significant(P<0.05). There was a negative correlation between serum IL-27 and IL-17 (r=-0.372, P=0.035) in the study group, while there was a positive correlation between IL-27 and IL-10 (r=0.524, P=0.026), and there was no correlation between IL-17 and IL-10 (r=0.519, P=0.318). Conclusion: The levels of IL-27 and IL-10 in the patients with allergic rhinitis are lowly expressed, but the level of IL-17 is highly expressed. IL-27 may have immunomodulatory effects on IL-17 and IL-10. |
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