| 文晓凤,郑 洁,雷亚兰,刘 杰,孙 虹,夏 敏,彭芳昕,胡 芳,陈碧娟.GnRHR-Ⅱ在子宫内膜的分布及表达变化规律研究[J].,2017,17(14):2718-2720 |
| GnRHR-Ⅱ在子宫内膜的分布及表达变化规律研究 |
| Research of the Distribution and Expressive Disciplinarian of GnRHR-Ⅱ in Endometrial |
| 投稿时间：2016-08-31 修订日期：2016-09-25 |
| DOI：10.13241/j.cnki.pmb.2017.14.029 |
| 中文关键词: GnRHR-Ⅱ 子宫内膜 增生期 分泌期 |
| 英文关键词: GnRHR-Ⅱ Endometrial Proliferative Secretory |
| 基金项目: |
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| 中文摘要: |
| 摘要 目的：研究促性腺激素释放激素Ⅱ型受体（GnRHR-Ⅱ）在子宫内膜的分布及表达变化规律。方法：选择2015年1月～2016年7月期间我院收治的100例女性不孕患者，经诊断性刮宫技术获取50例增生期子宫内膜组织与50例分泌期子宫内膜组织，分别作为研究组与对照组；采用免疫组织化学染色法检测两组子宫内膜基质细胞与腺上皮GnRHR-Ⅱ的表达。结果：增生期、分泌期子宫内膜均有GnRHR-Ⅱ分布；研究组子宫内膜基质细胞的GnRHR-Ⅱ表达明显高于对照组，而腺上皮则明显低于对照组，差异有统计学意义（P＜0.05）。结论：GnRHR-Ⅱ在子宫内膜增生期与分泌期均有表达，且在膜基质细胞与腺上皮均有分布，其分布于表达变化规律在一定程度上与子宫内膜容受性有关，有望成为评估子宫内膜容受性的标记物。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the distribution and expressive disciplinarian of GnRHR-Ⅱ in endometrial. Methods:Selected 100 cases of patients with female infertility who treated in our hospital from January 2015 to July 2016, after diagnostic curettage technique to obtain 50 cases of proliferative endometrium and 50 cases of secretory phase endometrium, and as the research group and the control group; Expression of GnRHR- II in two groups of endometrial stromal cells and glandular epithelium were detected by immunohistochemical staining. Results: The distribution of GnRHR- in the endometrium of proliferative phase and secretory phase; The expression of GnRHR- II in endometrial stromal cells was significantly higher in the research group than in the control group, the gland epithelium was significantly lower than that of the control group, the difference was statistically significant (P<0.05). Conclusion: The expression of GnRHR- II was expressed in the proliferative phase and secretory phase of endometrium, and the distribution of the membrane stromal cells and glandular epithelium, its distribution in expression changes in a certain degree with Endometrial Receptivity about, is expected to become the assessment of endometrial receptivity markers. |
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