张永祥,陈晓丰,刘耀华,滕 雷,赵世光.5-ALA在胶质瘤光动力治疗应用的进展[J].,2017,17(11):2155-2157 |
5-ALA在胶质瘤光动力治疗应用的进展 |
Review of Current Applications of 5-ALA-PDT in Glioma Treatment |
投稿时间:2016-04-23 修订日期:2016-05-18 |
DOI:10.13241/j.cnki.pmb.2017.11.041 |
中文关键词: 胶质瘤 5-氨基乙酰丙酸 光动力治疗 |
英文关键词: Glioma, 5-aminolevulinic acid(5-ALA) Photodynamic therapy(PDT) |
基金项目:国家自然科学基金面上项目(81172388) |
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中文摘要: |
摘要:胶质瘤作为常见的颅内恶性肿瘤,传统的手术与放疗化疗联合的治疗方法难以取得令人满意的治疗效果。光动力治疗作为治疗恶性肿瘤有效的辅助方法,在胶质瘤治疗中得到广泛应用。5-氨基乙酰丙酸(5-aminolevulinic acid, 5-ALA)是在光动力治疗中应用最多的光敏剂前体物质。多年来针对5-氨基乙酰丙酸(5-aminolevulinic acid, 5-ALA)在胶质瘤光动力治疗中的研究主要集中在如何增强光动力效应,这也是许多神经外科医生的兴趣所在。本文结合相关文献,对5-ALA在胶质瘤光动力治疗的研究进展及未来在此领域面临的挑战进行了综述。 |
英文摘要: |
ABSTRACT: Malignant gliomas exhibiting local invasiveness show poor prognosis despite treated with a combination of surgery, chemotherapy, and ionizing radiation. Photodynamic therapy(PDT) has been proven to be an effective adjuvant treatment option for vari- ous cancers, including glioma. 5-aminolevulinic acid has been widely applied in clinical studies as the most applicable precursor of a photosensitizer in PDT. Researches on this project maily focus on enhance the efficiency of PDT, which arouses interests of many neuro- surgeons. This article focuses on the current applications of 5-ALA in glioma PDT. |
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