| 刘颖 蔡黔 乔如丽 黄亚琼 赵庆丽△.Rac1 和Cdc42 在乳腺癌中的表达和临床意义[J].,2015,15(1):92-95 |
| Rac1 和Cdc42 在乳腺癌中的表达和临床意义 |
| Expression and Clinical Significances of Rac1 and Cdc42 in Breast Cancer |
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| DOI： |
| 中文关键词: 乳腺癌 Rac1 Cdc42 表达 临床意义 |
| 英文关键词: Breast cancer Rac1 Cdc42 Expression Clinical significance |
| 基金项目:国家自然科学基金项目(81170400) |
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| 中文摘要: |
| 目的：研究Rac1 和Cdc42 在人乳腺癌中的表达及临床意义。方法：收集339 例人乳腺癌组织样本，通过免疫组化的方法检
测Rac1 和Cdc42 的表达情况，并分析其与乳腺癌临床病理学特征间的相关性。结果：Rac1 和Cdc42 在正常乳腺组织中几乎不表
达，而在肿瘤组织的阳性表达率分别为35.9%和38.5%，均较正常乳腺组织显著升高，差异均具有统计学意义(P＜0.001 和P＜
0.05)。卡方检验分析表明，二者的表达与患者的年龄、肿瘤大小、组织分化程度、HER2 状态无关(P>0.05)，而与TNM分期、淋巴结
转移、肿瘤侵袭、ER状态和Ki-67 表达有相(P＜0.05)。相关性分析表明，Rac1 和Cdc42 的表达与高TNM 分期(r 分别为0.443 和
0.295；P 均＜0.001)、淋巴结转移阳性(r 均为0.480 和0.562；P 均＜0.001)、肿瘤侵袭(r 分别为0.412 和0.440；P 均＜0.001)、ER 阴
性表达(r分别为-0.517 和-0.342；P 均＜0.001)以及Ki-67 高表达(r分别为0.338 和0.454；P均＜0.001)呈正相关。结论：在乳腺癌
组织中，Rac1 和Cdc42 作为癌基因表达增加，可能在乳腺癌恶性进程中发挥重要作用。 |
| 英文摘要: |
| Objective:To investigate the expression and clinical significances of Rac1 and Cdc42 in human breast cancer.Methods:The expression of Rac1 and Cdc42 in 339 cases of human breast cancer specimens were detected by immunohistochemistry. The correlations
of Rac1 and Cdc42 expression with breast cancer were also analyzed.Results:The expression of Rac1 and Cdc42 in breast cancer
were 35.9%and 38.5%respectively, which were significantly higher than those of the normal breast tissue (P＜0.001, P＜0.05). The chi
square test suggested that Rac1 or Cdc42 expression had no correlation with the age, tumor size, histology, HER2 status of breast cancer
(P>0.05), but was correlated with TNMstage, lymph node metastasis, tumor invasion, ER status and Ki-67 expression (P<0.05). Correlation
analysis suggested that the expressions of Rac1 and Cdc42 were positively correlated with advance TNM stage (r=0.443 or 0.295;
P<0.001), positive lymph node metastasis (r=0.480 or 0.562; P<0.001), tumor invasion (r=0.412 or 0.440; P<0.001), negative ER status
(r=-0.517 or -0.342; P<0.001) and high Ki-67 level (r=0.338 or 0.454; P<0.001).Conclusion:In breast cancer, the expression of Rac1
and Cdc42 increased and correlated with the tumor progression. Rac1 and Cdc42 may play key roles in the progression of breast cancer. |
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