| 谢晓华 赵芳 王丽杰 刘培红 王海侠 马肃 王秀梅.骨涎蛋白在大鼠磨牙第三期牙本质形成过程中的表达[J].,2014,14(28):5451-5453 |
| 骨涎蛋白在大鼠磨牙第三期牙本质形成过程中的表达 |
| Expression of Bone Sialoprotein in the TertiaryDentin of Rat Molars |
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| DOI： |
| 中文关键词: 原发性牙本质 第三期牙本质 骨涎蛋白 |
| 英文关键词: Primary dentin(PD) Tertiary dentin(TD) Bone sialoprotein (BSP) |
| 基金项目:黑龙江省自然科学基金（面上项目）（H201418） |
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| 中文摘要: |
| 目的：观察大鼠牙髓修复第三期牙本质形成过程中骨涎蛋白(bone sialoprotein，BSP)的表达变化及意义。方法：选取6 周龄
雄性Wistar 大鼠10 只，建立实验大鼠模型，利用免疫组化法检测大鼠第三期牙本质中骨涎蛋白的表达情况。结果：盖髓2 周后，
在盖髓处下方有第三期牙本质形成。与原发性牙本质（PD）相比，第三期牙本质小管数目少且形态不规则。BSP 在原发性牙本质中
没有表达，但在盖髓下方和髓角下第三期牙本质中都有表达。结论：BSP可能通过参与羟基磷灰石（HA）的形成以及调节新分化的
成牙本质细胞向新形成的牙本质基质的粘附来参与早期的第三期牙本质的生成。 |
| 英文摘要: |
| Objective:To analyze the expression and distribution of bone sialoprotein (BSP) in tertiary dentin (TD).Methods:10
six-week male Wistar rats were selected and made to establish the experiment model. The expression of bone sialoprotein was detected
by immunolocalization.Results:Two weeks after the operation, the region on the cavity bottom formed tertiary dentin. Dentinal tubules
in TD were more irregular in shape and fewer in number than PD. At post-operative 2 weeks, BSP was present in TD, but not in PD. TD
showed certain similarities to TD under the corner of pulp.Conclusion:It is indicated that the odontoblasts would produce a hard tissue
in a rapid pace. These findings suggest that in response to the surgical injury, the newly differentiated odontoblasts altered their synthesis
of the dentinogenesis-related proteins, and produced a hard tissue that is an intermediate between dentin and bone. |
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