| 付文博 魏育涛 罗波 薛亚军 胡思远.MicroRNA：潜在的新型食管癌生物标记[J].,2014,14(25):4984-4986 |
| MicroRNA：潜在的新型食管癌生物标记 |
| MicroRNA: a New Potential Esophagus Cancer Biomarker |
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| DOI： |
| 中文关键词: 微小RNA 食管癌 诊断 生物标记 |
| 英文关键词: microRNA Esophageal cancer Diagnosis Biomarker |
| 基金项目:兵团卫生科技基金（2014BB019） |
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| 中文摘要: |
| MicroRNA(miRNA)为长约23 个核苷酸非编码的内源性微小RNA，在各种调节通路中发挥重要的基因调节作用，主要通过
靶向mRNA 3'非翻译端,抑制或降解mRNA，调控细胞发育、凋亡、增殖及分化等生命活动。到目前为止, miRNA为人们理解肿瘤
的发生发展提供了新的角度,展示了其作为肿瘤标志物的巨大潜能。食管癌是常见的恶性肿瘤之一，越来越多的证据表明miRNA
与食管癌存在密切联系。本文就食管癌的发生发展，病理分类，血清学标记物，耐药性与miRNA表达特点的关系展开论述。 |
| 英文摘要: |
| MicroRNA (miRNA) are endogenous approximately 23 nucleotide noncoding RNA molecules that play important
gene-regulatory roles in diverse regulation pathways, including those involved in cell development, differentiation, proliferation, and
apoptosis by targeting mRNAs for cleavage or translational repression. To date, miRNAs have given us a new perspective to understand
carcinogenesis and demonstrated the potential role to act as cancer biomarkers. Esophageal cancer is one of the most lethal human
cancers in China. Growing evidence has showed a close connection between miRNAs and esophageal cancer. In this review, information
regarding the relationship between the esophageal cancer development, pathological classification，plasma marker，chemoresistance and
the expression characteristic of miRNAs is discussed. |
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