| 刘鑫远 禹亮 张健 王磊.okemon及其在肿瘤中的研究进展[J].,2014,14(3):575-577 |
| okemon及其在肿瘤中的研究进展 |
| Progress on the Research of Pokemon and its Function in Tumors |
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| DOI： |
| 中文关键词: Pokemon ARF 癌症 |
| 英文关键词: Pokemon ARF Carcinoma |
| 基金项目:黑龙江省卫生厅科研课题(2010-039)；哈尔滨医科大学第一医院科研基金(2009L05) |
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| 中文摘要: |
| Pokemon 基因即POK 红系髓性致癌因子，也被称为FBI -1 ，LRF ，OCZF ，TIP ，它是POK 转录抑制物家族成员之一，其编
码的产物具有BTB / POZ 域和锌指结构,它是第一个被发现的可变阅读框基因ARF ( Alternative reading frame ，ARF )的特异性
转录抑制物，Pokemon 通过特异抑制ARF 转录来调控细胞周期、诱导肿瘤发生、促进肿瘤的发生发展，在一些人类肿瘤如食管鳞
癌、肺癌、结肠癌、人贲门癌、膀胱癌，前列腺癌和乳腺癌等肿瘤组织中具有较高的表达水平。Pokemon 的特殊性在于还能与其它
癌基因如Bcl-2，MDM2 等结合之后发挥作用来促进其他癌基因的活性。因此可以认为Pokemon 是肿瘤的总开关，对Pokemon 基
因的进一步研究有助于为肿瘤的诊断和治疗提供新的途径和方法。 |
| 英文摘要: |
| The Pokemon gene that is POK erythroid myeloid carcinogen, also called the FBI -1, LRF, OCZF, TIP, it is one of the
POK transcription inhibitor family members, encoding product has BTB / POZ domain and zinc finger, it is the first to be found in the
variable reading frame gene ARF( Alternative reading frame ,ARF ) specific transcription inhibitor. Pokemon which inhibitates the ARF
transcriptional specifically is to regulate the cell cycle and induce tumor to promote tumor development. It has a high-leveled expression
in some human tumors such as esophageal squamous cell carcinoma, lung cancer, colon cancer, people cardia cancer and bladder cancer,
prostate cancer, breast cancer and other tumor tissues. The specificity of Pokemon is to promote the role of other oncogenes. Therefore，
Pokemon is considered to be the master switch of tumors. The further research of the Pokemon gene is to help to provide new ways and
means for the diagnosis and treatment of tumors. |
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