| 钱泽南钱会南△ 熊斌许红吴海霞.脾虚大鼠脑内IL-1β、IL-2 表达的变化及益气扶正中药的干预研究*[J].,2012,12(27):5218-5220 |
| 脾虚大鼠脑内IL-1β、IL-2 表达的变化及益气扶正中药的干预研究* |
| Expression of Interleukin-1β, Interleukin-2 and Interventional Mechanism ofChinese Medicinal with Actions of Replenishing Qi and Reinforce theHealthy Qi in Rat Spleen-DeficiencyModel* |
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| DOI： |
| 中文关键词: 脾虚大鼠 细胞因子 IL-1β IL-2 益气扶正中药 |
| 英文关键词: Spleen-deficiency rats Cytokines Interleukin-1β Interleukin-2 Chinese medicinal with actions of replenishing qi and
reinforce the healthy qi |
| 基金项目:国家自然科学基金项目（30772685） |
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| 中文摘要: |
| 目的：研究脾虚模型大鼠脑内白细胞介素1β(IL-1β)、白细胞介素2(IL-2) 的活性表达，以及扶正益气中药的干预作用。方法：
40 只大鼠随机分成4 组，正常组、模型组、治疗1 组( 四君子汤组)、治疗2 组( 玉屏风散组) ，每组各10 只。采用苦降泻下、饮食失
节加劳倦过度法建立大鼠脾虚模型，采用免疫组化法检测下丘脑腹侧核、海马CA1 区的IL-1β 和IL-2 表达变化与四君子汤玉屏
风散的治疗作用。结果：IL-1β 在海马CA1 区和下丘脑腹侧核表达明显降低，IL-2 在海马CA1 区和下丘脑腹侧核表达明显降低；
四君子汤治疗组IL-1β 和IL-2 在上述脑区表达明显上升；玉屏风散治疗组IL-1β 和IL-2 在上述脑区表达呈紊乱变化现象。结论：
益气扶正中药四君子汤、玉屏风散可能通过影响免疫器官、调控细胞因子IL-1β 和IL-2 活性表达而调节机体免疫功能。 |
| 英文摘要: |
| Objective: To study the changes of expressions of interleukin-1β, interleukin-2 in spleen-deficiency rat model，and the
interventional effects of Chinese medicinal with actions of replenishing qi and reinforce the healthy qi. Methods: All rats ( n = 40) were
randomly divided into the normal group，model group, treatment group 1 ( T group 1, treated with Sijunzi Decoction) and treatment group
2 ( T group 2, treated with Yupingfeng Powder, each n = 10 ). The spleen-deficiency model was established in rats by using the methods
of purgation, improper diet and over strain. The expressions of IL-1β, IL-2 in the ventral nucleus of hypothalamus and CA1 zone of
hippocampus，and therapeutic effects of Sijunzi Decoction and Yupingfeng Powder were detected by applying immunohistochemistrical
assay and in situ hybridization. Results: In the model group the IL-1β, IL-2 expression decreased significantly. In T group 1 the IL-1β,
IL-2 expressions increased significantly; In T group 2 changed disorderly in the ventral nucleus of hypothalamus and CA1 zone of
hippocampus. Conclusion: Sijunzi Decoction and Yupingfeng Powder，with the actions of replenishing qi and reinforce the healthy qi，
can regulate the immunologic function of the body through influencing immune organs and controlling the expressions of brain IL-1β and
IL-2. |
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