| 刘韵资1 陈基快2 张懿1 张婷1 蒋春雷1.细胞因子和脂肪细胞因子在非酒精性脂肪肝中研究新进展[J].,2012,12(24):4787-4790 |
| 细胞因子和脂肪细胞因子在非酒精性脂肪肝中研究新进展 |
| Novel Insights into the Cytokines and Adipocytokines of Non-alcoholicFatty Liver Disease |
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| DOI： |
| 中文关键词: 非酒精性脂肪性肝炎 细胞因子 发病机制 |
| 英文关键词: Non-alcoholic fatty liver disease Adipocytokines Pathogenesis |
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| 中文摘要: |
| 非酒精性脂肪性肝病（Non-alcoholic fatty liver disease，NAFLD）是遗传- 环境- 代谢应激相关因素所致的以肝细胞脂肪变性
为主的临床病理综合征，其发生、发展均与细胞因子及脂肪细胞因子密切相关。本文回顾了肿瘤坏死因子-α（Tumor necrosis factor-α，
TNF-α）、白介素-6 （interleukin-6，IL-6）、脂联素等经典因子与NAFLD 的关系研究新进展，并介绍了视黄醇结合蛋白4（retinol
binding protein4，RBP4）、apelin、visfatin 等新脂肪细胞因子在NAFLD 中的作用。 |
| 英文摘要: |
| Non-alcoholic fatty liver disease （NAFLD）is a group of genetic-environment- metabolic clinical syndrome mainly
caused by hepatic steatosis. The development of NAFLD is closely related with various cytokines and adipocytokines. This article reviewed
the pivotal role of cytokines such as TNF-α, IL-6 and adiponectin in the pathological progress of NAFLD, and new adipocytokines
Retinol Binding Protein 4（RBP4）; apelin and visfatin were also included in the review. |
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