| 陈志刚1,2 雷明军2 丁梓华1 阳煜1 刘小明1.鼻咽癌的CT 显像与VEGF 和p53 蛋白表达的相关性研究[J].,2012,12(22):4294-4297 |
| 鼻咽癌的CT 显像与VEGF 和p53 蛋白表达的相关性研究 |
| The Relationship between CT Imaging and VEGF/p53 Protein Expressionin Nasopharyngeal Carcinoma |
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| DOI： |
| 中文关键词: 鼻咽癌 CT VEGF p53 |
| 英文关键词: Nasopharyngeal carcinoma CT VEGF P53 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨鼻咽癌患者CT 表现与血管内皮细胞生长因子以及p53 蛋白表达的相关性。方法：选择经病理确诊的鼻咽癌患者
36 例，行螺旋CT 扫描并采用免疫组化法检测肿瘤组织中VEGF 和p53 蛋白的表达，分析影像学特征与VEGF 及p53 蛋白表达
的相关性。结果：鼻咽癌患者肿瘤组织中VEGF 的表达与CT 征象中的侵及后鼻孔、颅底骨质破坏及颈部淋巴结转移正相关，p53
蛋白的表达与颈部淋巴结转移正相关。结论：肿瘤组织中VEGF 和p53 蛋白表达与鼻咽癌的部分CT 影像学特征相关，可作为评
价鼻咽癌CT 表现恶性度及预后的指标。 |
| 英文摘要: |
| Objective: To investigate the relationship between CT image features and vascular endothelial growth factor and p53
protein expression of patients with nasopharyngeal carcinoma. Methods: 36 pathologically confirmed NPC patients were included in this
study. All patients were scanned by spiral CT and the expression of VEGF/p53 protein in tumor tissue was detected by immunohistochemical
method. The relationship between the imaging features and the expression of VEGF/p53 was analyzed. Results: The expression of
VEGF is positively related with CT signs of invasion and choanal destruction of skull base and cervical lymph node metastasis. The
expression of p53 protein is positively related with CT signs of cervical lymph node metastasis in nasopharyngeal carcinoma patients.
Conclusion: The VEGF/p53 protein expression is related with the CT images characteristics in nasopharyngeal carcinoma. This could be
a potential evaluation index of CT manifestations and prognosis. |
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