| 于海丰黄旭甄春英王永亮叶磊光刘宝刚.GRP78 的表达与非小细胞肺癌生物学特性及预后的关系[J].,2012,12(22):4259-4236 |
| GRP78 的表达与非小细胞肺癌生物学特性及预后的关系 |
| The Relationship between Expression of GRP78 and Its BiologicalCharacteristic, Prognosis in Non-Small Cell Lung Cancer |
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| DOI： |
| 中文关键词: 非小细胞肺癌 GRP78 预后 |
| 英文关键词: Non-small cell lung cancer Glucose regulated protein 78 Prognosis |
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| 中文摘要: |
| 目的：探讨GRP78 在非小细胞肺癌和癌旁组织中的表达情况，并研究其与生物学特征及临床预后的关系。方法：收集非小细
胞肺癌术后切除标本88 例，及其癌旁组织20 例作为对照。采用免疫组织化学方法检测GRP78 的表达。结果：GRP78 在非小细胞
肺癌组织和癌旁组织中的表达有统计学差异。GRP78 的表达与非小细胞肺癌的临床分期、分化程度有关，而与患者性别、年龄和
病理类型无关。非小细胞肺癌中GRP78 高表达的患者生存时间短于GRP78 低表达的患者。GRP78 的表达情况是影响非小细胞
肺癌患者手术预后的独立危险因素。结论：非小细胞肺癌患者的GRP78 的表达可能与肿瘤细胞的发生及发展有关，GRP78 可以
作为一个预测非小细胞肺癌患者预后的分子标志物。 |
| 英文摘要: |
| Objective: To explore the expression of endoplasmic reticulum stress molecular chaperone GRP78 （glucose regulated
protein,GRP78）in non-small cell lung cancer tissues and para-cancerous lung tissues.We investigated relationship between the expression
of GRP78 and its biological characteristic,prognosis in non-small cell lung cancer. Methods: We collected 88 cases of surgically resected
specimens in non-small cell lung cancer and 20 cases para-cancerous tissues for contrast. Immunohistochemistry method was used to
detect the expression of GRP78 protein. Results: The expression of GRP78 in non-small cell lung cancer tissues and para-cancerous lung
tissues had statistical significance. The levels of GRP78 expression were correlated with extent of differentiation, clinical stage, but not
with patients' sex, age and pathologic features. GRP78 expression was independent p rognotic factor of non-small cell lung cancer.
Conclusions: The expression of GRP78 in non-small cell lung cancer tissues was related with non-small cell lung cancer development.
GRP78 may be used as a molecular marker to prognosis of non-small cell lung cancer. |
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