| 张玉尤庆山△ 孙迪李香兰吴静.恶性胸腔积液综合治疗进展[J].,2012,12(17):3358-3361 |
| 恶性胸腔积液综合治疗进展 |
| Progress of Comprehensive Treatment for Malignant Pleural Effusions |
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| DOI： |
| 中文关键词: 恶性胸腔积液 治疗 进展 |
| 英文关键词: Malignant pleural effusions Management Progress |
| 基金项目: |
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| 中文摘要: |
| 恶性胸腔积液是恶性肿瘤累及胸膜，或是发生胸膜转移所致。它是癌症晚期常见的并发症，治疗难度大，预后较差。约有一
半以上的癌症患者晚期出现胸腔积液。大量胸腔积液可引起胸痛，咳嗽，呼吸困难等，影响病人生存质量，治疗不及时可危及生
命。因此我们治疗恶性胸腔积液的主要目的是缓解症状，有效的清除胸腔积液并防止它的再次蓄积，改善患者的生存质量，延长
生存时间。目前，恶性胸腔积液治疗的方法较多，但是没有标准的治疗方法，总体疗效有限。由于其预后不佳，临床上多以姑息治
疗手段为主。常见的方法有胸腔穿刺术，胸腔置管引流术，化学胸膜固定术，及胸膜剥除术等。生物免疫制剂协同其他方法治疗恶
性胸腔积液被广泛应用于临床，疗效满意，毒副反应小。本文综合性的回顾恶性胸腔积液的治疗方法，就恶性胸腔积液的治疗进
展进行简要分析。 |
| 英文摘要: |
| Malignant pleural effusions (MPE) may be caused by primary tumor and metastatic malignancy to the thorax. It is a
common and difficult complications of advanced malignant diseases, with poor prognosis. About more than half of the the patients with
late cancer produce pleural effusion at some point. Devastating consequences of MPE, such as dyspnea, cough and pain, severely
deteriorate the quality of life, even threatened the life of these patients.Therefore the main goal of the treatment of MPE is to make effort
to clear the pleural fluid, prevent the re-accumulation, try to improve the quality of life and prolong the survival time. At present, there are
a lot of therapies, but there is no standard treatment, the optimal treatment is controversial and the general effect is limited. The treatment
options range from simple thoracentesis to more other methods such as chemical and mechanical pleurodesis, catheter drainage,
pleurectomy and so on. Biological agents were widely used, with better effect and less toxic. Because of its poor prognosis, several
studies favor to local palliative approaches. This article reviews the comprehensive treatment methods and current approaches to the
management of malignant pleural effusion, and show some advice to the future. |
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