| 凌月明1 陈金玉2 姜明建1 黄珍珍1.NSE、CEA 和CYFRA21-1 测定对胸腔积液的诊断价值[J].,2012,12(17):3273-3274 |
| NSE、CEA 和CYFRA21-1 测定对胸腔积液的诊断价值 |
| Diagnostic Values of NSE, CEA and CYFRA21-1 in Pleural Effusion |
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| DOI： |
| 中文关键词: 胸腔积液 神经元烯醇化酶 癌胚抗原 细胞角蛋白19 |
| 英文关键词: Pleural effusion Neuron Specific Enolase Carcinoembryonic Antigen CYFRA21-1 |
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| 中文摘要: |
| 目的：探讨神经元烯醇化酶（NSE）、癌胚抗原（CEA）和细胞角蛋白19（CYFRA21-1）测定对胸腔积液的诊断价值。方法：选择
我院2009 年4 月～2011 年9 月收治的胸腔积液患者89 例作为研究对象，按照胸腔积液性质分为两组，良性组47 例，恶性组42
例，对两组的NSE、CEA 和CYFRA21-1 测定结果进行比较分析。结果：恶性组患者血清和胸腔积液中NSE、CEA 和CYFRA21-1
水平均明显高于良性组，组间差异有统计学意义（P＜0.05）；NSE、CEA 和CYFRA21-1 联合检测对恶性胸腔积液的敏感性均明显
高于单独NSE、CEA 和CYFRA21-1 检测，差异有统计学意义（P＜0.05）。结论：NSE、CEA 和CYFRA21-1 测定对胸腔积液具有临
床诊断价值，且三者联合检测能够明显提高诊断敏感性。 |
| 英文摘要: |
| Objective: To investigate the diagnostic value of NSE, CEA and CYFRA21-1 determination of pleural effusion.
Methods: From April 2009 to September 2011 in our hospital, 87 patients of pleural effusion were selected as the study object, they were
divided into two groups according to the nature of pleural effusion, 47 cases of benign group and 42 cases of malignant group, the
determination results of two groups were compared and analyzed. Results: The NSE, CEA and CYFRA21-1 in serum and pleural
effusion of benign group were significantly higher than the malignant group, the differences were statistically significant between two
groups (P＜0.05); the sensitivity of NSE, CEA and CYFRA21-1 combined detection of malignant pleural effusion were significantly
higher than NSE, CEA or CYFRA21-1 alone detection, and the difference was statistically significant between two groups (P＜0.05).
Conclusions: NSE, CEA and CYFRA21-1 determination of pleural effusion has diagnostic value, NSE, CEA and CYFRA21-1 combined
detection can significantly improve the diagnostic sensitivity. |
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