| 朱伟1 朱晓丹2 葛海燕2.神经轴突生长抑制因子Nogo 家族的研究进展*[J].,2012,12(15):2968-2970 |
| 神经轴突生长抑制因子Nogo 家族的研究进展* |
| Research Progress of the Neurite Outgrowth Inhibitor Nogo Family* |
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| DOI： |
| 中文关键词: 神经轴突生长抑制因子 受体 神经再生 胚胎发育 细胞凋亡 |
| 英文关键词: Neurite outgrowth inhibitor Receptor Nerve regeneration Fetus development Cell apotosis |
| 基金项目:国家自然科学基金项目(30900662)；上海市自然科学基金项目（08411965600） |
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| 中文摘要: |
| Nogo 家族是一类神经轴突生长抑制因子家族，目前成员包括Nogo-A，Nogo-B，Nogo-C 三个亚型。Nogo 家族成员因C 末端
具有保守的RHD 结构域而归属于RTNs 家族，表明它们的分布和功能与内质网密切相关。Nogo 家族C 末端还具有一个进化保
守的66 氨基酸的功能段称为Nogo-66，体外表达的Nogo-66 片段具有抑制神经突生长的作用。Nogo 家族成员结构上的区别主要
表现在不同剪切长短的N 末端序列。Nogo-A 主要在中枢和外周神经系统中广泛分布，Nogo-C 主要分布在骨骼肌，而Nogo-B 则
几乎遍布于各种组织与细胞之中。目前，发现可介导Nogo 胞内信号转导通路的受体主要是膜外糖蛋白偶联的NgR 和跨膜受体
p75NTR 组成的共受体，但NgR 与Nogo-A 在胚胎发育中时空表达并不同步提示可能还有其它受体存在。虽然Nogo 家族作为神
经轴突生长抑制因子被发现，但越来越多的研究表明其可能在胚胎发育、细胞凋亡或神经退行性变等重大事件中扮演重要角色。
本文拟就Nogo 家族迄今为止突出的研究进展作一综述，旨在为下一步的功能研究工作提供理论参考和依据。 |
| 英文摘要: |
| Nogo family is a kind of neurite outgrowth inhibitor, which includes three family members as far as now. Nogo family
belongs to the RTNs family because of the common RHD domains in their C-terminal sequence, which indicates their location and
function are related to regulation in cell. Nogo family members also have an conservative 66 amino-acids functional peptide(Nogo-66) in
evolutionary process, which has been demonstrated effective in inhibiting neurite outgrowth in vitro. The main difference in family
members exists in their different length of N-terminal sequence. Nogo-A has been found sufficient in the CNS or PNS. Nogo-C has been
found only in skeloton-musle tissue. While Nogo-B is found almost everywhere in vivo. Presently, the recognized receptors of Nogo are
co-receptors including GPI-anchored glycoprotein receptor （NgR）and trans-membrane receptor p75NTR，through which can onset the
signaling transduction of ligand in cell. But the obvious different location of Nogo-A and NgR neither in spatial nor in time series when
fetus develope, so that other receptors have not been found maybe exist. Although Nogo family is found to be a group of neurite
outgrowth inhibitors, more and more researches show their essential roles in important affairs in vivo such as fetus development, cell
apoptosis and nerve degradation etc. In this article, we try to review the most outstanding progresses of the Nogo family researches up to
now, in order to offer the reference of background information to the future. |
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