| 杨东 张红.MicroRNAs-126（miR-126）的生物学功能[J].,2012,12(14):2773-2777 |
| MicroRNAs-126（miR-126）的生物学功能 |
| The Biological Function of MicroRNAs-126（miR-126） |
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| DOI： |
| 中文关键词: miR-126 血管新生 肿瘤 |
| 英文关键词: MiR-126 Neovascularization Tumor |
| 基金项目:教育部科学研究重点项目（210062）；中国博士后基金（20080440907）；黑龙江省政府博士后基金（LRB-0-305） |
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| 中文摘要: |
| MicroRNAs(MiRNAs)负向调控基因的表达，在细胞分化和细胞功能调节中起着重要作用，且涉及血管新生。应用克隆和测
序方法，检测出miR-126 在人内皮细胞高度表达。MiR-126 与许多肿瘤关系密切，miR-126 通过信号传导通路负向调控肿瘤细胞
增殖、迁移和侵袭，并且抑制肿瘤生长延长患者存活率；相反的，在某些肿瘤中miR-126 也可通过促进肿瘤细胞血管生长加速肿
瘤进展，可能是未来作为相关肿瘤治疗的手段之一。本文就miR-126 在生理进程和病理进程的表达及其作用进行综述。 |
| 英文摘要: |
| MicroRNAs(MiRNAs) are negative regulators of gene expression that play a key role in cell-type specific differentiation
and modulation of cell function. Some miRNAs have been proposed to be involved in neovascularization, such as miR-126, which has
been proved to be specifically and highly expressed in human endothelial cells (EC). MiR-126 is relevant in many tumors and miR-126
have been reported to impair cancer progression through signaling pathways that control tumor cell proliferation, migration, invasion, and
survival; Conversely, miR-126 may have a supportive role in the progression of cancer as well, which might be medisted by the
promotion of blood vessel growth, and miR-126 may be a novel therapeutic target for relevant diseases. We will summarize the current
knowledge of miR-126 for physiological processes and pathological processes here. |
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