| 曹智君 叶志中 董慧娟 陈杰 尹志华.成年女性系统性红斑狼疮血清中抗黄体抗体与月经异常
的相关性研究[J].,2012,12(14):2724-2726 |
| 成年女性系统性红斑狼疮血清中抗黄体抗体与月经异常
的相关性研究 |
| Anti-corpus Luteum Antibody and Menstrual Irregularity in AdultYoung Patients with Systemic Lupus Erythematosus |
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| DOI： |
| 中文关键词: 抗黄体抗体 月经 系统性红斑狼疮 |
| 英文关键词: Anti-corpus luteum antibodies Menstrual disturbance Systemic lupus erythematosus |
| 基金项目:深圳医学重点学科建设资助项目（2005C10） |
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| 中文摘要: |
| 目的：探讨成年女性系统性红斑狼疮（SLE）血清中抗黄体抗体与月经异常的相关性。方法：收集SLE 患者及正常对照者的
临床资料，详细记录入选研究对象的月经及生育情况，同时记录抗核抗体(ANA) 等自身抗体的测定结果。采用酶联免疫吸附试验
( ELISA) 法检测患者血清中抗黄体抗体。结果：在入选的69 例成年女性SLE 患者中，26（38%）例患者抗黄体抗体阳性。而在40
例健康对照者中，仅2（5%）例出现抗黄体抗体阳性。在入选的69 例SLE 患者中，29（42%）例患者的月经正常，40（58%）例患者出
现月经异常。在40 例健康对照者中，31（78%）例患者的月经正常，仅9（21%）例患者出现月经异常。有月经异常的SLE 患者中抗
黄体抗体的阳性率显著高于无月经异常的SLE 患者（66% vs 18%, P<0.01），而在健康对照者中则未见有显著性差异。结论：SLE
患者中抗黄体抗体的阳性率为38%，并可能与SLE 的月经异常相关。 |
| 英文摘要: |
| Objective: To verify the presence of anti-corpus luteum antibodies (anti-CoL) in systemic lupus erythematosus (SLE),
as well as establish its possible correlation with menstrual disturbances in patients with SLE. Methods: Clinical data of 69 consecutive
patients who fulfilled 4 or more of the ACR 1997 revised criteria for SLE were studied and were compared with 40 age-matched healthy
controls, including anti-CoL. Results: 26 (38%) patients with SLE, and 2 (5%) of the healthy controls tested positive for anti-CoL. The
presence of anti- CoL was significantly correlated to menstrual disturbance (P<0.01) in SLE patients. Conclusions: The presence of anti-
CoL was 38% in SLE, and may correlate to menstrual disturbance. |
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