| 谭永振 武凯歌 张竞之 李云鹏 文小敏.王氏连朴饮对脾胃湿热证大鼠行为、肾上腺指数及血清Cort 的影响[J].,2012,12(14):2623-2625 |
| 王氏连朴饮对脾胃湿热证大鼠行为、肾上腺指数及血清Cort 的影响 |
| Regulation ofWangshi-Lianpu-Yin Decoction on Behavior, Adrenal Indexand Serum Cortisol of Rats with Spleen and StomachDamp-Heat Syndrome |
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| DOI： |
| 中文关键词: 王氏连朴饮 脾胃湿热证 旷场实验 肾上腺指数 Cort |
| 英文关键词: Wangshi-Lianpu-Yin Damp-heat syndrome of spleen-stomach Open field test Adrenal index Cortisol |
| 基金项目:国家中医药管理局中医药科学技术研究专项(06-07JP33)；广东省中医药局科研基金(2008195) |
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| 中文摘要: |
| 目的：观察王氏连朴饮对脾胃湿热证大鼠的行为学、肾上腺指数及血清皮质醇(Cort)的调控作用。方法：将45 只雄性Wistar
大鼠随机分为正常对照组、模型组、王氏连朴饮（高、中、低剂量）组。利用复合因素复制脾胃湿热证动物模型。通过旷场实验观察
大鼠行为学改变，称量法计算肾上腺指数，采用放射免疫法检测大鼠血清Cort 的水平。结果：造模成功后大鼠行为发生改变，王氏
连朴饮各剂量组对大鼠行为均有恢复作用，但各剂量组间无显著性差异；大鼠肾上腺指数增高，血清Cort 升高(P<0.05)，王氏连朴
饮各剂量组对其均有降低作用，以中剂量组效果最好且有显著性差异(P <0.05)。结论：王氏连朴饮对脾胃湿热证大鼠行为、肾上腺
指数和血清Cort 有干预作用，这可能是王氏连朴饮清热祛湿的机制之一。 |
| 英文摘要: |
| Objective: To investigate the regulation effect of Wangshi-Lianpu-Yin (WLY) decoction on behavior, adrenal index
and serum Cort (cortisol) of rats with spleen and stomach damp-heat syndrome (SSDHS). Methods: Forty-five male Wister rats were
randomly divided into five groups: normal control group (NCG), model group (MG), WLY high (HWG), moderate (MWG) and low
dosage groups (LWG). The behavior of rats was monitored with open-field test. Adrenal index were calculated by quantified method. The
levels of serum Cort were detected by RIA method. Results: Experiments showed that there were changes in the behavior of rats with
SSDHS．WLY decoction with various doses all had effect on the behavior of the rats, but no statistical differences could be seen
between groups treated with different doses (P >0.05). Compared with normal control group, the adrenal index and serum Cort of the
model group increased significantly(P <0.05). WLY decoction of different doses all reduced the adrenal index and serum Cort(P>0.05 or
P<0.05), and especially the MWG had best outcome. Conclusions: WLY decoction can control the behavior, the adrenal index and serum
Cort of the rats with SSDHS. This may be one of the functions of the WLY. |
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