| 伏鹏荣1 丛晓东1△ 张云1 蔡宝昌1,2△.糖尿病心肌病发病机制，靶点和中药治疗[J].,2012,12(6):1179-1182 |
| 糖尿病心肌病发病机制，靶点和中药治疗 |
| Mechanisms and Therapeutic Targets of Traditional Chinese Medicine（TCM）in Treating Diabetic Cardiomyopathy |
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| DOI： |
| 中文关键词: 糖尿病心肌病 靶点 中药治疗 氧化应激 炎症因子 细胞保护 |
| 英文关键词: Diabetic cardiomyopathy Target Traditional Chinese medicine Oxidative stress Inflammatory Cell protection |
| 基金项目:科技部国家重大新药创制计划(NO：2009ZX09308) |
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| 中文摘要: |
| 高血糖诱发心肌代谢紊乱，引起心肌肥大和纤维化，使心脏舒张和收缩功能发生异常，诱发心衰，造成糖尿病心肌病。其病
理过程可能与心肌中激活NADPH 氧化酶、内质网应激、内皮素和活性氧通路等炎症因子有关。本文综述糖尿病心肌病的主要机
制，相关靶点及中药治疗，为中药治疗糖尿病提供理论依据。 |
| 英文摘要: |
| Hyperglycemia induces myocardial metabolism disorder，causing myocardial hypertrophy and fibrosis, then diastolic
and systolic dysfunction and heart failure occur, resulting in diabetic cardiomyopathy (DC). The pathological process may involve multiple
mechanisms and targets, including activation of NADPH oxidase, endoplasmic reticulum stress and the endothelin-reactive oxygen
species pathway in the myocardium. The main mechanisms and targets of DC are reviewed to provide the theoretic considerations in
treating DC with TCM. |
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