| 杨海燕李晓虹张映红.非小细胞肺癌组织中CDK2 及β-catenin 的表达[J].,2011,11(20):3897-3898 |
| 非小细胞肺癌组织中CDK2 及β-catenin 的表达 |
| Expression of CDK2 andβ-Catenin in Non Small-Cell Lung Cancer |
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| DOI： |
| 中文关键词: 肺癌 CDK2 β-catenin |
| 英文关键词: Carcinomatous metastasis CDK2 β-catenin |
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| 中文摘要: |
| 目的：观察非小细胞肺癌组织中CDK2 及β-catenin 的表达，探讨CDK2 及β-catenin 与肺癌转移的关系。方法：48 例非小细
胞肺癌患者分为转移组和未转移组。手术取肺癌组织，分别采用实时荧光定量PCR 法和western blot 法检测脑组织中CDK2 及
β-catenin 蛋白和mRNA 的表达。结果：转移组肺癌组织中CDK2 及β-catenin 蛋白和mRNA 的表达明显高于未转移组（P<0.01）。
结论：CDK2 及β-catenin 与肺癌转移有关。 |
| 英文摘要: |
| Objective: To observe the expression of CDK2 and b-catenin in non small-cell lung cancer tissue and to investigate the
relationship of CDK2 and b-catenin with metastatic lung cancer. Methods: 48 non small-cell lung cancer patient were divided into
metachoresis and non metachoresis groups. Real-time FQ-PCR and western blot were applied respectively to detect the protein and
mRNA expression of CDK2 and b-catenin in carcinoma tissue. Results: The protein and mRNA expression of CDK2 and b-catenin was
obviously higher in metachoresis group than in non metachoresis group. Conclusion: The expression of CDK2 and b-catenin may be
correlated with lung cancer metastasis. |
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