| 王也李汉梁林丽娣林鑫王冰梅.经典Wnt 信号通路在牙齿发育中的研究新进展[J].,2011,11(13):2575-2577 |
| 经典Wnt 信号通路在牙齿发育中的研究新进展 |
| Recent advances About Canonical Wnt Pathway in Tooth Development |
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| DOI： |
| 中文关键词: Wnt 牙齿发育 β-catenin |
| 英文关键词: Wnt Tooth development β-catenin |
| 基金项目:国家级实验教学示范中心项目（2009ls025） |
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| 中文摘要: |
| 经典Wnt 信号通路是参与胚胎及器官发育的四大信号传导途径之一，在牙齿发育中扮演了重要的角色。本文对其中的
β-catenin，Lef1，Apc，Axin2 这4 个关键因子在牙齿发育中研究的新进展做了简要的概述：β-catenin 在间充质中会调控多个信
号，影响牙上皮和间充质相互作用；Lef1 会和Tcf 家族一道调控上皮细胞命运；Apc 能抑制多余牙齿的形成；Axin2 在牙晚期发育
中影响牙本质的形成。通过这些因子的研究，希望人们能在牙齿再生等生物医学工程上有新的突破。 |
| 英文摘要: |
| Canonical Wnt signaling pathway is one of the main four categories of signal transduction pathway involving in embryo
and organ development. It also plays an important role in the tooth development. In this paper, we briefly write an overview about
the new research of β-catenin,Lef1,Apc,Axin2 in tooth development: β-catenin affects the interaction between epithelium and mesenchyme
by regulating other signals; the LEF/TCF complex can regulate the fate of dental epithelium cell; Apc inhibits supernumerary
tooth formation during embryo genesis; and Axin2 has the influence of development of the crown and root during pre- and postnatal
tooth development.So here we hope it may bring a new breakthrough among tooth regeneration and other bioengineerings. |
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