| 修彬华魏敏李华杨江河闫志强刘绍明.维生素E 对癫痫大鼠认知功能障碍的治疗作用及其可能机制[J].,2011,11(11):2094-2097 |
| 维生素E 对癫痫大鼠认知功能障碍的治疗作用及其可能机制 |
| Vitamin E for Cognitive Dysfunction of Rats with Epilepsy |
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| DOI： |
| 中文关键词: 癫痫持续状态 维生素E 认知功能障碍 |
| 英文关键词: Status epilepticus Vitamin E Cognitive deficits |
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| 中文摘要: |
| 目的：探讨维生素E(VitE)对癫痫大鼠认知功能障碍的治疗作用及其可能机制。方法：将30 只成年雄性SD 大鼠随机分为健
康对照组、单纯致痫组(SE 组)、VitE [按体重100mg/(kg·d) ]干预组(VitE 组)。采用Morris 水迷宫实验方法检测致癫后大鼠学习记
忆功能变化，同时检测脑组织匀浆中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)、谷胱甘肽(GSH)、丙二醛(MDA)的水
平。结果：(1) SE 组大鼠寻找平台的潜伏期明显长于对照组，具有统计学意义(P<0.05)，VitE 组寻找平台的潜伏期相对于SE 组显
著缩短(P< 0.05)。撤离平台后，SE 组大鼠在平台所在象限的停留时间明显短于对照组(P<0.05)，VitE 治疗后大鼠在平台所在象限
的停留时间较SE 组显著延长(P<0.05)。(2) SE 组SOD、GSH-PX、GSH 显著下降，MDA 明显增高，VitE 干预组SOD、GSH-PX、GSH
显著增高,而MDA 明显下降，具有统计学意义(P<0.05)。结论：VitE 可改善癫痫持续状态后大鼠认知功能，其可能机制是通过减轻
海马区的氧化应激反应减轻海马区的损伤，从而实现改善认知功能。 |
| 英文摘要: |
| Objective: The purpose of the study was to investigate the effects of vitamin E (VitE) on cognitive deficits induced by
status epilepticus (SE) and the possible mechanism in terms of oxidative stress in hippocampus．Methods: A total of 30 male
Sprague-Dawley rats (200±20 g) were randomly assigned to one of the following groups: (n =10 in each group): Control group、SE
group and Vit E group. Severe cognitive deficits in lithium-pilocarpine seizure model was tested by the water maze task. Glutathione
(GSH) and Maleic Dialdehyde(MDA) content of the homogenate of Hippocampus were measured; The activity of Superoxide Dismutase
(SOD) and glutathione peroxidase (GSH-PX)in the homogenate of Hippocampus were detected. Results: Vitamin E could attenuate
SE-induced cognitive deficits. Biochemical experiments revealed that SE can significantly increase content of MDA, decrease content of
GSH and decreased the activities of SOD and GSH-PX in the homogenate of Hippocampus, which can be reversed by VitE. Conclusions:
Vit E exhibits therapeutic potential for SE-induced cognitive deficits, which is most likely related, at least in part, to its anti-oxidative
stress actions in hippocampus. |
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