| 顾奕1 于明琨2 吕立权3 孙克华3 卢亦成2 侯立军1.p53、BCL-2、Caspase-3 等凋亡相关蛋白在大鼠脑损伤中的表达及意义[J].,2011,11(11):2030-2033 |
| p53、BCL-2、Caspase-3 等凋亡相关蛋白在大鼠脑损伤中的表达及意义 |
| Expression of p53, Bcl-2 and Caspase-3 in Rats with Brain Injury |
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| DOI： |
| 中文关键词: 脑外伤 p53 bcl-2 caspase-3 免疫组化 |
| 英文关键词: Brain injury p53 BCL-2 Caspase-3 Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：检测脑外伤大鼠中p53、bcl-2 及caspase-3 表达，并分析其与脑外伤之间的关系，为脑损伤患者预后提供部分参数依
据。方法：建立脑外伤大鼠实验动物模型，用免疫组化方法检测p53、Bcl-2 和Caspase-3 的表达。结果：脑创伤后在创伤周围区的神
经元会发生凋亡，凋亡的发生可能与p53、bcl-2、caspase-3 等基因及蛋白的调节有关。结论：脑创伤后在创伤周围区的神经元会发
生凋亡，凋亡的发生可能与p53、bcl-2、caspase-3 等基因及蛋白的调节有关。 |
| 英文摘要: |
| Objective: To detect the expression of p53、Bcl-2 and Caspase-3 in brain injury rat and analyze its relationship with
brain damage, to provide some parameters according for the prognosis of patients with brain damage. Methods: Establish brain injury rat
experimental animal model, detected the expression of p53, Bcl-2 and Caspase-3 by immunohistochemistry. Results: The immunohistochemical
results in brain injury rat experimental animal model: the brain injury model group compared with the normal group and sham
operation group, p53 and Caspase-3 expression increased significantly, Bcl-2 expression dropped significantly, differences were statistically
significant (P<0.01). Conclusion: After brain trauma, apoptosis of the neurons around the trauma will happen and it is possibly concerned
with the regulation of genes and proteins p53, BCL-2 or caspase-3. |
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