| 李巨仕1 汤恢焕2.环氧合酶-2 在肿瘤中的表达及其抑制剂在肿瘤中的应用进展[J].,2011,11(5):972-975 |
| 环氧合酶-2 在肿瘤中的表达及其抑制剂在肿瘤中的应用进展 |
| Progress of Cyclooxygenase-2 Expression in Tumors and Its InhibitorsApplication in Anti-tumor |
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| DOI： |
| 中文关键词: 环氧合酶-2 COX-2 抑制剂 肿瘤 |
| 英文关键词: Cyclooxygenase-2 Cyclooxygenase-2 inhibitors Tumor |
| 基金项目: |
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| 中文摘要: |
| 环氧合酶-2（Cyclooxygenase-2，COX-2）是前列腺素合成过程中一重要的限速酶，COX-2 的过度表达及其前列腺素产物与
多种肿瘤的发生、发展关系密切，COX-2 抑制剂通过抑制肿瘤细胞增殖，诱导肿瘤细胞凋亡，阻断致癌物的代谢，减弱肿瘤介导的
免疫抑制，调节抑制血管生成，抑制肿瘤细胞侵袭，环氧合酶非依赖抑癌途径，对原癌基因及抑癌基因的影响等途径影响肿瘤的
发生发展，这方面的研究为针对COX-2 的抗肿瘤策略打开新的视野，提供新的线索。 |
| 英文摘要: |
| Cyclooxygenase-2 (COX-2) is the process of prostaglandin synthesis is an important rate-limiting enzyme, COX-2
over-expression of prostaglandin products with a variety of tumors, the development of close. COX-2 inhibiting tumor cell added induce
tumor cell apoptosis,blocking the metabolism of carcinogens, decreased tumor-mediated immunosuppression, inhibition of angiogenesis
regulation, inhibition of tumor cell invasion, cyclooxygenase-independent tumor suppressor pathway, and suppression of oncogene the
impact of cancer genes affect the tumor development pathway, esearch in this area is for COX-2 anti-tumor strategy to open new horizons
and provide new clues. |
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