| 张玉花1 蔡蕊2 刘江华3 朱春雨3 解洪荣3.MPTP/MPP+ 诱导神经元凋亡的机制研究[J].,2011,11(5):964-967 |
| MPTP/MPP+ 诱导神经元凋亡的机制研究 |
| The study of MPTP/MPP+-induced apoptosis of neurons |
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| DOI： |
| 中文关键词: 1- 甲基-4- 苯基-1,2,3,6- 四氢吡啶（MPTP） 1- 甲基-4- 苯基吡啶离子（MPP+） 帕金森病（PD） 凋亡 |
| 英文关键词: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) 1-methyl-4-phenylpyridinium ion (MPP+) Apoptosis |
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| 中文摘要: |
| 1982 年人们发现1- 甲基-4- 苯基-1,2,3,6- 四氢吡啶（MPTP）能诱发PD，它的有效成分是1- 甲基-4- 苯基吡啶离子（MPP+）。
目前，MPTP/MPP+ 广泛的被用作诱导PD 实验模型的有效药物，可诱导神经元细胞发生凋亡性死亡。MPTP/MPP+ 诱导细胞凋亡的
机制牵涉Bcl-2、p53、caspase 家族、JNK 通路、ERK 通路和PARP 等多种机制，它们共同参与了MPTP/MPP+ 诱导的细胞凋亡的调
控和执行阶段。本文主要综述MPTP/MPP+ 诱导的神经元细胞凋亡机制。 |
| 英文摘要: |
| Since 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its active neurotoxic metabolite 1-Methy l-4-phenyl-
pyridinium (MPP+) have been shown to induce PD, people have done lots of research on the neurotoxicity of MPTP/MPP+. So,
MPTP/MPP+ has been widely used to be neurotoxin to induce experimental model of PD. MPTP/MPP+ can induce neuronal apoptosis
through various mechanisms, involving Bcl-2, p53, caspase, JNK pathway, ERK pathway and PARP etc. These mechanisms
collaborative participate in the control and performance of neuronal apoptosis induced by MPTP/MPP+. This article mainly review the
apoptosis mechanisms induced by MPTP/MPP+. |
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