| 兰州生物制品研究所.单链抗体的研究进展[J].,2011,11(4):795-797 |
| 单链抗体的研究进展 |
| Progress in Single-Chain Antibody |
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| DOI： |
| 中文关键词: 单链抗体 展示系统 |
| 英文关键词: Single-chain antibody or ScFv Display system |
| 基金项目: |
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| 中文摘要: |
| 单链抗体即单链抗体可变区片段（single-chain antibody variable fragment，or ScFv）是由抗体重链可变区和轻链可变区通过一
段10-25个氨基酸的连接肽连接而成，其分子质量小，穿透力强，特异性好，免疫原性低，在免疫学和医学方面得到了广泛应用。本
文就单链抗体的结构设计、展示系统、表达和应用方面做一综述。 |
| 英文摘要: |
| The single-chain antibody (single-chain antibody variable fragment，or ScFv ) is made up of the variable region of the
heavy and light chains, which are connected together by a polypeptide linker of typically 10-25 amino acid residues in length. The advantages
of ScFv are the small size of molecular mass, higher affinity for target antigens, and imposing minimal antigenicity in recipient
hosts. So the single-chain antibody had been widely applied in immunology and medical field. In this paper, the molecular design of single-
chain antibodies, display systems, expression, and applications were reviewed. |
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