| 朱例例刘磊李玉梅陈勐刘博郑玉婷胡成乙.吸入M3受体拮抗剂对稳定期COPD肺功能的影响[J].,2011,11(3):505-507 |
| 吸入M3受体拮抗剂对稳定期COPD肺功能的影响 |
| Effect of M3 Receptor Antagonist on Lung Function in Stable COPD |
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| DOI： |
| 中文关键词: M3受体拮抗剂 慢性阻塞性肺疾病 肺功能 |
| 英文关键词: M3 receptor antagonist Chronic obstructive pulmonary disease Lung function |
| 基金项目:黑龙江省卫生厅资助项目(2006-212) |
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| 中文摘要: |
| 目的：评价噻托溴铵干粉剂对中、重度稳定期慢性阻塞性肺疾病(COPD) 患者肺功能的影响。方法：采用随机对照研究140
例COPD患者，噻托溴铵组使用噻托溴铵干粉剂，对照组使用氨茶碱片，总观察时间12周，治疗前后测定肺功能。结果：治疗后噻
托溴铵组深吸气量、第1秒用力肺活量和用力肺活量明显改善，分别增加了102 mL，256 mL和154 mL，对照组改善不明显，仅分
别增加了10mL，08mL，15mL。结论：噻托溴铵能改善中、重度稳定期COPD患者的肺功能，可提高患者的生活质量。 |
| 英文摘要: |
| Objective: To research the effect of M3 receptor antagonist (tiotropium) on lung function in stably moderate and severe
chronic obstructive pulmonary disease (COPD). Methods: A randomized controlled clinical trail was conducted in 140 patients with
COPD. 80 patients were treated by tiotropium (18μg , qd inhaled) and 60 patients were treated by placebo for aminophylline 12 weeks.
Results: Tiotropium provided significantly improvement in inspiratory capacity (IC), forced expiratory volume in one second(FEV1) and
forced vital capacity (FVC) than baseline, IC, FEV1 and FVC in tiotropium group was increased 102mL, 256 mL and 154 mL respectively,
and it was significantly higher than that aminophylline group (10 mL,08mL and 15 mL respectively). Conclusion: Tiotropium was
an effective bronchodaliator on improving lung function and health status in patients with stably moderate and severe COPD. |
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