| 王伟杜美陈正望△.NKT 细胞在动脉粥样硬化中的作用*[J].,2011,11(1):158-160 |
| NKT 细胞在动脉粥样硬化中的作用* |
| Roles of NKT cells in atherosclerosis* |
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| DOI： |
| 中文关键词: 自然杀伤T 细胞 免疫反应 双向调节 动脉粥样硬化 |
| 英文关键词: NKT cell Immune response Two-way adjustment Atherosclerosis |
| 基金项目:国家自然科学基金（30370647，3470823） |
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| 中文摘要: |
| 然杀伤T 细胞（natural killer T cell, NKT 细胞）是一种特殊的淋巴细胞亚群，具有部分T 细胞和NK 细胞的特征。与这些细
胞不同的是，NKT 细胞不仅能够识别醣脂类抗原，还在激活后产生促炎症因子和抗炎症因子。由于这些特性，NKT 细胞在炎症和
免疫方面的研究越来越热。动脉粥样硬化是一种受免疫调节的炎性疾病，因此对NKT 细胞在该疾病中作用的研究也逐渐开展起
来。 |
| 英文摘要: |
| Natural killer T cell (NKT cell) is a specialized subset of lymphocytes, which shares with some characteristics of both
T cell and Natural kill cell (NK cell). Nevertheless, unlike both of them, NKT cell can recognize glycolipid antigens, and produce some
pro-inflammatory and anti-inflammatory cytokines on activation. Due to these characteristics, more and more researches about NKT cells
in inflammatory and immune aspects are turned up. It is becoming very clear that atherosclerosis is a chronic inflammatory disease with
both innate and adaptive immunity in pathological mechanism. Therefore, researches on roles of NKT cell in the disease are getting hot. |
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