| 张巨峰 黄 倩.选择性复制型腺病毒介导的自杀基因HSV -tk 在
肿瘤基因治疗中的应用[J].,2006,6(7):51-53 |
| 选择性复制型腺病毒介导的自杀基因HSV -tk 在
肿瘤基因治疗中的应用 |
| The application of conditionally replication adenovirus -mediatedsuicide gene HSV-tk in the tumor gene therapy |
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| DOI： |
| 中文关键词: 自杀基因 选择性复制型腺病毒 肿瘤基因治疗 |
| 英文关键词: Suicide gene therapy Conditionally replication adenovirus Tumor gene therapy |
| 基金项目:国家高技术研究发展计划“973” 项目资助(NO .2004CB518800) |
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| 中文摘要: |
| 自杀基因治疗是肿瘤基因治疗的手段之一, 治疗效果与自杀基因能否被高效、选择性的导入肿瘤细胞有关。肿瘤选择
性复制型腺病毒(Conditionally replication adenovirus, CRAds)可以特异性的在肿瘤细胞中复制, 在复制的同时所携带的治疗基因也
大量表达。由CRAds 介导的自杀基因, 实现了对肿瘤的病毒治疗和基因治疗的结合, 提高了治疗效率和使用复制型腺病毒的安
全性。 |
| 英文摘要: |
| Suicide gene therapy is one of the approaches of tumor gene therapy .The effect of suicide gene therapy approach is concerned
with genes can be delivered efficiently and selectly to the tumor site .Conditionally replication of adenovirus in tumor tissue leads to amplification
of the input dose at the tumor site , while the adenovirus-mediated gene can also largely replicate .Conditionally replication adenovirus that
contain sucide gene combine the advantages of virotherapy and suicide gene therapy , in addition, are improved significantly in both efficacy and
safety . |
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