| Objective: To explore the predictive value of electrocardiogram repolarization related parameters combine with serum brain natriuretic peptide (BNP) and 25 hydroxyvitamin D3 [25- (OH) - D3] for malignant arrhythmia (MA) after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction. Method: 120 patients with acute myocardial infarction who underwent PCI in our hospital from June 2022 to June 2024 were selected, they were divided into combined group (n=25) and non combined group (n=95) based on whether MA occurred within 72h after PCI. All patients underwent routine electrocardiogram examination, the mean R-wave (RR) interval, QRS start to T end (QT) interval, T wave time, corrected QT (QTc) interval, T wave peak to T wave end (Tp-e) interval, T wave amplitude, and other electrocardiogram repolarization related parameters between two groups were measuredand compared. The serum BNP and 25- (OH) - D3 levels between two groups were detected and compared. Influencing factors were analyzed by single and multiple logistic regression analysis. Predict value was analyzed by receiver operating characteristic (ROC) curve. Result: The mean QT interval and QTc interval in the combined group were significantly lower than those in the non combined group (P<0.05). The serum BNP levels in the combined group was significantly higher than that in the non combined group, and the serum 25- (OH) - D3 level was significantly lower than that in the non combined group (both P<0.05). Univariate analysis showed that there were statistically significant differences in terms of age, number of vascular lesions, cardiac troponin I (cTnI), and creatine kinase MB (CK-MB) (P<0.05). Multiple logistic regression analysis showed that serum CK-MB and BNP were independent risk factors for MA) after PCI in patients with acute myocardial infarction, while mean QT interval, mean QTc interval, and elevated 25- (OH) - D3 were independent protective factors (P<0.05). Draw ROC curves, and the results show that the mean QT interval, mean QTc interval, serum BNP, and 25- (OH) - D3 levels alone predict the area under the curve(AUC) for postoperative MA after PCI was 0.762 (0.706-0.817), 0.822 (0.772-0.871), 0.809 (0.757-0.862), and 0.709 (0.642-0.775), respectively, the AUC for combined prediction was 0.882 (0.843-0.920). Conclusion: Electrocardiogram repolarization related parameters such as mean QT interval and QTc interval for MA after PCI in patients with acute myocardial infarction were lower, serum BNP is increased, and 25- (OH) - D3 is decreased, the combined detection of these indicators has high predictive value for postoperative MA after PCI. |
