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| 高压氧联合石杉碱甲治疗对脑梗死后血管性认知障碍患者认知功能及神经炎症的影响 |
| Influence of Hyperbaric Oxygen Combine With Huperzine A Treatment on Cognitive Function and Neuroinflammation in Patients With Vascular Cognitive Impairment After Cerebral Infarction |
| 投稿时间：2025-05-15 修订日期：2025-05-15 |
| DOI： |
| 中文关键词: 高压氧 石杉碱甲 脑梗死 血管性认知障碍 认知功能 神经炎症 |
| 英文关键词: Hyperbaric oxygen Huperzine A Cerebral infarction Vascular cognitive impairment Cognitive function Neuroinflammation |
| 基金项目:广西医药卫生自筹经费计划课题立项（Z2016144） |
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| 中文摘要: |
| 目的：观察高压氧联合石杉碱甲治疗对脑梗死后血管性认知障碍（VCI）患者认知功能及神经炎症的影响。方法：本研究为回顾性研究，选择我院2023年1月~2024年10月期间接受高压氧联合石杉碱甲治疗的34例脑梗死后VCI患者为观察组。另采用1:1配比的病例对照研究方法，选择同时期接受单纯高压氧治疗治疗的34例患者为对照1组，接受单纯石杉碱甲治疗的34例患者为对照2组。对比三组的临床疗效、认知功能[简易智力状态检查量表（MMSE）评分、蒙特利尔认知评估量表（MoCA）评分]、日常生活活动能力[Barthel指数（BI）]、神经功能[美国国立卫生研究院卒中量表（NIHSS）、神经元特异性烯醇化酶（NSE）、脑源性神经营养因子（BDNF）]、炎症介质[超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β]和不良反应发生情况。结果：观察组的临床总有效率高于对照1组、对照2组（P<0.05）。治疗后，观察组的MMSE评分、MoCA评分、Barthel指数高于对照1组、对照2组（P<0.05）。治疗后，观察组的NIHSS、NSE低于对照1组、对照2组，BDNF高于对照1组、对照2组（P<0.05）。治疗后，观察组的hs-CRP、IL-1β、TNF-α低于对照1组、对照2组（P<0.05）。三组不良反应发生率组间对比未见差异（P>0.05）。结论：高压氧联合石杉碱甲治疗脑梗死后VCI患者可提高临床总有效率，改善患者的认知功能及降低神经炎症水平。 |
| 英文摘要: |
| Objective:To observe the effects of hyperbaric oxygen combine with huperzine A treatment on cognitive function and neuroinflammation in patients with vascular cognitive impairment(VCI) after cerebral infarction. Methods:This study was a retrospective study. 34 patients with VCI after cerebral infarction who were treated with hyperbaric oxygen combined with huperzine A in our hospital from January 2023 to October 2024 were selected as the observation group. Additionally using 1:1 matched case-control study method, 34 patients who were treated with hyperbaric oxygen alone during the same period were selected as the control group 1 , and 34 patients who were treated with huperzine A alone were selected as the control group 2.Compared the clinical efficacy,cognitive function [Mini Mental State Examination (MMSE) score, Montreal Cognitive Assessment (MoCA) score], activities of daily living [Barthel index (BI)], neurological function [National Institutes of Health Stroke Scale (NIHSS), neuron specific enolase (NSE), brain-derived neurotrophic factor (BDNF)], inflammatory mediators [high-sensitivity C-reactive protein (hs-CRP), tumor necrosis factor-α (TNF-α), interleukin (IL) -1β] and incidence of adverse reactions among three groups.Result:The total clinical effective rate of the observation group was higher than that of control group 1 and control group 2 (P<0.05). After the treatment, the MMSE score, MoCA score and Barthel index of the observation group were higher than those of control group 1 and control group 2 (P<0.05). After the treatment, the NIHSS and NSE in the observation group were lower than those in control group 1 and control group 2, and the BDNF was higher than that in control group 1 and control group 2(P<0.05).After the treatment, the levels of hs-CRP,IL-1β and TNF-α in the observation group were lower than those in control group 1 and control group 2(P<0.05).There was no difference in the incidence of adverse reactions among the three groups(P>0.05).Conclusion: Hyperbaric oxygen combine with huperzine A in the treatment of VCI after cerebral infarction can increase the total clinical effective rate, improve patients'' cognitive function and reduce levels of neuroinflammation. |
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