| Objective:To analyze the therapeutic effect of Jiawei Baitouweng decoction combine with bifidobacterium tetravaccine tablets on ulcerative colitis (UC) base on interleukin (IL)-23/IL-17 axis and intestinal flora. Methods: Using random number table method, 138 UC patients who were admitted to our hospital from May 2022 to May 2024 were divided into control group (69 cases, conventional treatment) and study group (69 cases, conventional treatment combined with Jiawei Baitouweng decoction). The changes of traditional chinese medicine syndrome scores, intestinal mucosal barrier function indexes, serum IL-23, IL-17 levels and fecal intestinal flora were compared between two groups. Results: Compared with control group, the main symptom scores, secondary symptom scores, total scores, diamine oxidase (DAO), endotoxin (ET), D-lactic acid (D-LA), IL-23, IL-17, yeast value, clostridium value were lower, and bifidobacterium value and lactobacillus value were higher in study group after treatment (P<0.05). Conclusion: Jiawei Baitouweng decoction combine with bifidobacterium tetravaccine tablets in the treatment of UC, which can effectively improve the clinical symptoms of patients, and contribute to the recovery of intestinal mucosal barrier function, which may be related to the regulation of fecal intestinal flora and IL-23/IL-17 axis. |
