| 邓 斌,曾春梅,白 莹,李颖媛,梁光丽.年龄相关性白内障患者血清和房水Hcy、25-(OH)-D、HMGB1与氧化应激指标和炎症细胞因子的相关性分析[J].现代生物医学进展英文版,2024,(18):3585-3589. |
| 年龄相关性白内障患者血清和房水Hcy、25-(OH)-D、HMGB1与氧化应激指标和炎症细胞因子的相关性分析 |
| Correlation Analysis of Hcy, 25-(OH)-D, HMGB1 and Oxidative Stress Indexes and Inflammatory Cytokines in Serum and Aqueous Humor of Patients with Age-Related Cataract |
| Received:January 31, 2024 Revised:February 28, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.18.035 |
| 中文关键词: 年龄相关性白内障 Hcy 25-(OH)-D HMGB1 氧化应激 炎症细胞因子 |
| 英文关键词: Age-related cataract Hcy 25-(OH)-D HMGB1 Oxidative stress Inflammatory cytokines |
| 基金项目:四川省卫生厅科研基金项目（1931392） |
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| 中文摘要: |
| 摘要 目的：探讨年龄相关性白内障（ARC）患者血清和房水同型半胱氨酸（Hcy）、25羟维生素D[25-(OH)-D]、高迁移率族蛋白B1（HMGB1）与氧化应激指标和炎症细胞因子的相关性。方法：选取2021年1月～2023年1月成都市第六人民医院收治的ARC患者135例作为ARC组和同期60名眼外伤患者作为对照组。检测血清和房水Hcy、25-(OH)-D、HMGB1、氧化应激指标[超氧化物歧化酶（SOD）、丙二醛（MDA）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-PX）]和炎症细胞因子[肿瘤坏死因子-α（TNF-α）、白细胞介素（IL）-1β、IL-6、IL-8]水平。Pearson相关性分析ARC患者血清和房水Hcy、25-(OH)-D、HMGB1与氧化应激和炎症细胞因子水平的相关性。结果：ARC组血清和房水Hcy、HMGB1、MDA、TNF-α、IL-1β、IL-6、IL-8水平高于对照组，25-(OH)-D、SOD、CAT、GSH-PX水平低于对照组（P＜0.05）。Pearson相关性分析显示，ARC患者血清和房水Hcy、HMGB1与SOD、CAT、GSH-PX呈负相关，与MDA、TNF-α、IL-1β、IL-6、IL-8呈正相关（P＜0.05）；25-(OH)-D与SOD、CAT、GSH-PX呈正相关，与MDA、TNF-α、IL-1β、IL-6、IL-8呈负相关（P＜0.05）。结论：ARC患者血清和房水Hcy、HMGB1水平升高，25-(OH)-D水平降低，与氧化应激和炎症细胞因子存在显著关联。Hcy、HMGB1、25-(OH)-D可能通过氧化应激和炎症反应参与ARC发生发展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between homocysteine (Hcy), 25-hydroxyvitamin D [25-(OH)-D], high mobility group protein B1(HMGB1) and oxidative stress indexes and inflammatory cytokines in serum and aqueous humor of patients with age-related cataract(ARC). Methods: 135 ARC patients admitted to The Sixth People's Hospital of Chengdu from January 2021 to January 2023 were selected as ARC group and 60 patients with ocular trauma in the same period were selected as control group. The levels of Hcy, 25- (OH)-D, HMGB1, oxidative stress indexes [superoxide dismutase (SOD), malondialdehyde (MDA), catalase (CAT), glutathione peroxidase (GSH-PX)] and inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin (IL) -1β, IL-6, IL-8] in serum and aqueous humor were detected. The correlation between serum and aqueous humor Hcy, 25-(OH)-D, HMGB1 and oxidative stress and inflammatory cytokine levels in ARC patients were analyzed by Pearson correlation analysis. Results: The levels of Hcy, HMGB1, MDA, TNF-α, IL-1β, IL-6 and IL-8 in serum and aqueous humor in ARC group were higher than those in control group, while the levels of 25-(OH)-D, SOD, CAT and GSH-PX were lower than those in control group(P<0.05). Pearson correlation analysis showed that, Hcy and HMGB1 in serum and aqueous humor of ARC patients were negatively correlated with SOD, CAT and GSH-PX, and positively correlated with MDA, TNF-α, IL-1β, IL-6 and IL-8 (P<0.05). 25-(OH)-D was positively correlated with SOD, CAT and GSH-PX, and negatively correlated with MDA, TNF-α, IL-1β, IL-6 and IL-8(P<0.05). Conclusion: The levels of Hcy and HMGB1 in serum and aqueous humor of ARC patients increase, and the level of 25-(OH)-D decrease, which is significantly correlate with oxidative stress and inflammatory cytokines. Hcy, HMGB1, 25-(OH)-D may be involve in the development of ARC through oxidative stress and inflammatory response. |
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