| 梁权满,宋天宇,容 皓,陈图刚,陈 灿.急性ST段抬高型心肌梗死合并射血分数保留的心力衰竭患者SII、FAR、CAR与PCI术中无复流的关系[J].现代生物医学进展英文版,2024,(18):3529-3534. |
| 急性ST段抬高型心肌梗死合并射血分数保留的心力衰竭患者SII、FAR、CAR与PCI术中无复流的关系 |
| Relationship between SII, FAR, CAR and No-Reflow during PCI in Patients with Acute ST-Elevation Myocardial Infarction and Heart Failure with Preserved Ejection Fraction |
| Received:December 26, 2023 Revised:January 21, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.18.024 |
| 中文关键词: 急性ST段抬高型心肌梗死 射血分数保留的心力衰竭 SII FAR CAR PCI 无复流 |
| 英文关键词: Acute ST-elevation myocardial infarction Heart failure with preserved ejection fraction SII FAR CAR PCI No-reflow |
| 基金项目:广东省自然科学基金面上项目（2023A1515010482) |
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| 中文摘要: |
| 摘要 目的：探讨急性ST段抬高型心肌梗死（STEMI）合并射血分数保留的心力衰竭（HFpEF）患者系统免疫炎症指数（SII）、纤维蛋白原/白蛋白比值（FAR）、C反应蛋白/白蛋白比值（CAR）与经皮冠状动脉介入治疗（PCI）术中无复流的关系。方法：前瞻性选取2020年5月～2023年5月155例在我院行直接PCI治疗的STEMI合并HFpEF患者，根据PCI术中血流情况分为无复流组35例和正常复流组120例。计算SII、FAR、CAR。STEMI合并HFpEF患者PCI术中无复流的因素采用多因素Logistic回归模型分析，绘制受试者工作特征（ROC）曲线分析SII、FAR、CAR对STEMI合并HFpEF患者PCI术中无复流的预测价值。结果：155例STEMI合并HFpEF患者PCI术中无复流发生率为22.58%（35/155）。与正常复流组比较，无复流组SII、FAR、CAR升高（P＜0.05）。STEMI合并HFpEF患者PCI术中无复流的独立危险因素为年龄增加和SII、FAR、CAR升高（P＜0.05）。SII、FAR、CAR单独与SII、FAR、CAR联合预测STEMI合并HFpEF患者PCI术中无复流的曲线下面积分别为0.811、0.800、0.788、0.940。结论：STEMI合并HFpEF患者SII、FAR、CAR升高是PCI术中无复流的独立危险因素，SII、FAR、CAR联合对STEMI合并HFpEF患者PCI术中无复流的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between systemic immune inflammatory index (SII), fibrinogen/albumin ratio (FAR), C-reactive protein/albumin ratio (CAR) and no-reflow during percutaneous coronary intervention (PCI) in patients with acute ST-elevation myocardial infarction (STEMI) and heart failure with preserved ejection fraction (HFpEF). Methods: 155 patients with STEMI and HFpEF who underwent direct PCI in our hospital from May 2020 to May 2023 were prospectively selected, patients were divided into no-reflow group (n=35) and normal-reflow group (n=120) according to the blood flow during PCI. SII, FAR and CAR were calculated. The factors of no-reflow during PCI in patients with STEMI and HFpEF were analyzed by multivariate Logistic regression model, the predictive value of SII, FAR and CAR for no-reflow during PCI in patients with STEMI and HFpEF were analyzed by drawn receiver operating characteristic (ROC) curve. Results: The incidence of no-reflow during PCI in 155 patients with STEMI and HFpEF was 22.58% (35/155). Compared with normal-reflow group, SII, FAR and CAR increased in no-reflow group (P<0.05). The independent risk factors for no-reflow during PCI in patients with STEMI and HFpEF were increased age and increased SII, FAR and CAR(P<0.05). The area under the curve of SII, FAR, CAR alone and SII, FAR, CAR combined to predict no-reflow during PCI in patients with STEMI and HFpEF was 0.811, 0.800, 0.788, 0.940 respectively. Conclusion: The increase of SII, FAR and CAR in patients with STEMI and HFpEF is an independent risk factor for no-reflow during PCI, the combination of SII, FAR and CAR has a high predictive value for no-reflow during PCI in patients with STEMI and HFpEF. |
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