| 马 晶,陈 淼,廖光冲,张岩鹏,龙训辉.电子支气管镜肺泡灌洗联合脾多肽对重症肺部感染的治疗效果、免疫功能及呼吸动力学指标影响[J].现代生物医学进展英文版,2024,(18):3494-3497. |
| 电子支气管镜肺泡灌洗联合脾多肽对重症肺部感染的治疗效果、免疫功能及呼吸动力学指标影响 |
| The Therapeutic Effect, Immune Function, and Respiratory Dynamic Indicators of Electronic Bronchoscopy Combined with Splenic Peptide in the Treatment of Severe Pulmonary Infection |
| Received:February 08, 2024 Revised:February 28, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.18.018 |
| 中文关键词: 支气管镜肺泡灌洗 脾多肽 重症肺部感染 临床疗效 免疫功能 呼吸力学 |
| 英文关键词: Bronchoscopic alveolar lavage Spleen peptide Severe pulmonary infection Clinical efficacy Immune function Respiratory mechanics |
| 基金项目:新疆维吾尔自治区自然科学基金项目(2022D01C808) |
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| 中文摘要: |
| 摘要 目的：探讨电子支气管镜肺泡灌洗联合脾多肽对重症肺部感染的治疗效果、免疫功能及呼吸动力学指标影响。方法：选取我院2021.1-2023.12收治的88例重症肺部感染患者，分为观察组与对照组，各组均为44例。所有患者均采取营养支持、解痉、吸氧、化痰、机械通气、抗感染等常规治疗，对照组患者实施电子支气管镜肺泡灌洗，观察组患者在对照组基础上增加脾多肽。对比其临床疗效，治疗前后炎症因子，呼吸动力学指标及免疫功能变化。结果：与对照组相，观察组治疗总有效率高（P＜0.05）；治疗后，两组患者炎症因子水平均降低，且与对照组相比，观察组较低（P＜0.05）；治疗后，两组患者呼吸力学指标均降低，且与对照组相比，观察组较低（P＜0.05）；治疗后，两组T细胞亚群指标均升高，且与对照组相比，观察组较高（P＜0.05）。结论：电子支气管镜肺泡灌洗联合脾多肽可改善重症肺部感染临床疗效，减轻机体炎症因子水平，改善呼吸动力学，提升免疫功能。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of electronic bronchoscope pulmonary alveolar lavage and splenic polypeptide on the treatment effect, immune function and respiratory dynamics indicators in severe lung infection. Methods: 88 cases of severe lung infection admitted to our hospital from January 2021 to December 2023 were divided into observation group and matched group, with 44 cases in each group. They were divided into an observation group and a matched group, with 44 cases in each group. All patients received routine treatments such as nutritional support, spasmolysis, oxygen therapy, phlegm reduction, mechanical ventilation, and anti infection. The matched group received electronic bronchoscopy bronchoalveolar lavage, while the observation group received an increase in spleen peptides on the basis of the matched group. Compare its clinical efficacy, changes in inflammatory factors, respiratory dynamics indicators, and immune function before and Post-treatment. Results: Compared with the matched group, the observation group had a higher total effective rate of treatment(P<0.05); Post-treatment, the levels of inflammatory factors in both groups of patients decreased, and compared with the matched group, the observation group was lower (P<0.05); Post-treatment, the respiratory mechanics indicators of both groups of patients decreased, and compared with the matched group, the observation group was lower(P<0.05); Post-treatment, the T cell subsets in both groups increased, and compared with the matched group, the observation group had a higher level(P<0.05). Conclusion: The combination of electronic bronchoscopy alveolar lavage and splenic peptide can improve the clinical efficacy of severe pulmonary infection, reduce the level of inflammatory factors in the body, improve respiratory dynamics, and enhance immune function. |
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