| 翟鸿烨,王 伟,张利军,袁 晖,白重阳,柳 琳,桂玉婷,翟 达.CD64指数、系统免疫炎症指数、CRP/Alb比值与肝癌肝部分切除术患者术后感染的关系[J].现代生物医学进展英文版,2024,(17):3342-3347. |
| CD64指数、系统免疫炎症指数、CRP/Alb比值与肝癌肝部分切除术患者术后感染的关系 |
| Relationship between CD64 Index, Systemic Immune Inflammation Index, CRP/Alb Ratio and Postoperative Infection in Patients with Partial Hepatectomy for Liver Cancer |
| Received:May 05, 2024 Revised:June 02, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.17.028 |
| 中文关键词: 肝癌 肝部分切除术 分化簇64指数 系统免疫炎症指数 C反应蛋白/白蛋白比值 感染 |
| 英文关键词: Liver cancer Partial hepatectomy Cluster of differentiation 64 index Systemic immune inflammation index C-reactive protein/albumin ratio Infection |
| 基金项目:陕西省自然科学基础研究计划项目（2022JQ-921） |
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| 中文摘要: |
| 摘要 目的：探讨分化簇64（CD64）指数、系统免疫炎症指数（SII）、C反应蛋白/白蛋白（CRP/Alb）比值与肝癌肝部分切除术（PR）患者术后感染的关系。方法：选取2021年1月～2023年10月在我院行PR的肝癌患者300例，根据是否发生术后感染分为感染组和无感染组，计算CD64指数、SII、CRP/Alb比值。采用多因素Logistic回归分析肝癌PR患者术后感染的因素，受试者工作特征（ROC）曲线分析CD64指数、SII、CRP/Alb比值对肝癌PR患者术后感染的预测价值。结果：300例肝癌PR患者术后感染发生率为21.33%（64/300）。与无感染组比较，感染组CD64指数、SII、CRP/Alb比值升高（P＜0.05）。多因素Logistic回归分析显示糖尿病、术中输血、引流管放置时间≥7 d和CD64指数、SII、CRP/Alb比值升高为肝癌PR患者术后感染的独立危险因素（P＜0.05）。CD64指数、SII、CRP/Alb比值联合预测肝癌PR患者术后感染的曲线下面积为0.910，大于CD64指数、SII、CRP/Alb比值单独预测的0.790、0.778、0.776。结论：CD64指数、SII、CRP/Alb比值升高为肝癌PR患者术后感染的独立危险因素，CD64指数、SII、CRP/Alb比值联合预测肝癌PR患者术后感染的价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between cluster of differentiation 64 (CD64) index, systemic immune inflammation index (SII), C-reactive protein/albumin (CRP/Alb) ratio and postoperative infection in patients with partial hepatectomy (PR) for liver cancer. Methods: 300 patients with liver cancer who underwent PR in our hospital from January 2021 to October 2023 were selected and divided into infection group and non-infection group according to whether postoperative infection occurred, the CD64 index, SII and CRP/Alb ratio were calculated. The factors of postoperative infection in patients with liver cancer PR were analyzed by multivariate Logistic regression analysis, the predictive value of CD64 index, SII and CRP/Alb ratio for postoperative infection in patients with liver cancer PR were analyzed by receiver operating characteristic (ROC) curve. Results: The incidence of postoperative infection in 300 patients with liver cancer PR was 21.33% (64/300). Compared with non-infected group, the CD64 index, SII and CRP/Alb ratio in infected group increased (P<0.05). Multivariate Logistic regression analysis showed that diabetes mellitus, intraoperative blood transfusion, drainage tube placement time ≥7 d and elevated CD64 index, SII, CRP/Alb ratio were independent risk factors for postoperative infection in patients with liver cancer PR (P<0.05). The area under the curve of CD64 index, SII and CRP/Alb ratio in predicting postoperative infection of PR patients with liver cancer was 0.910, which was greater than 0.790, 0.778 and 0.776 predicted by CD64 index, SII and CRP/Alb ratio alone (P<0.05). Conclusion: The increase of CD64 index, SII and CRP/Alb ratio are independent risk factor for postoperative infection in PR patients with liver cancer, the combination of CD64 index, SII and CRP/Alb ratio has higher value in predicting postoperative infection in PR patients with liver cancer. |
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