| 鹿 畅,陈中元,王经元,邓雪君,孙 彬.血清BNP、SII、TyG与急性心肌梗死合并2型糖尿病患者急诊PCI术后主要不良心血管事件的关系分析[J].现代生物医学进展英文版,2024,(17):3294-3299. |
| 血清BNP、SII、TyG与急性心肌梗死合并2型糖尿病患者急诊PCI术后主要不良心血管事件的关系分析 |
| Analysis of the Relationship between Serum BNP, SII, TyG and Major Adverse Cardiovascular Events after Emergency PCI in Patients with Acute Myocardial Infarction Combined with Type 2 Diabetes Mellitus |
| Received:March 23, 2024 Revised:April 18, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.17.019 |
| 中文关键词: 急性心肌梗死 2型糖尿病 经皮冠状动脉介入 B型利钠肽 全身免疫炎症指数 甘油三酯葡萄糖乘积指数 主要不良心血管事件 |
| 英文关键词: Acute myocardial infarction Type 2 diabetes mellitus Percutaneous coronary intervention B-type natriuretic peptide Systemic immune inflammation index Triglyceride glucose product index Major adverse cardiovascular events |
| 基金项目:山东省医药卫生科技发展计划面上项目（2017WSA07016） |
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| 中文摘要: |
| 摘要 目的：探讨血清B型利钠肽（BNP）、全身免疫炎症指数（SII）、甘油三酯葡萄糖乘积指数（TyG）与急性心肌梗死（AMI）合并2型糖尿病（T2DM）患者急诊经皮冠状动脉介入治疗（PCI）术后主要不良心血管事件（MACE）的关系。方法：选取山东第二医科大学附属益都中心医院2020年1月～2022年12月接受急诊PCI术的AMI合并T2DM患者170例，根据PCI术后1年是否发生MACE分为MACE组和非MACE组。检测血清BNP水平和计算SII、TyG。通过多因素Logistic回归分析AMI合并T2DM患者急诊PCI术后MACE的影响因素，受试者工作特征（ROC）曲线分析血清BNP、SII、TyG对AMI合并T2DM患者急诊PCI术后MACE的预测价值。结果：170例AMI合并T2DM患者急诊PCI术后1年MACE发生率为36.47%（62/170）。MACE组BNP、SII、TyG高于非MACE组（P＜0.05）。KILLIP分级≥Ⅱ级和BNP升高、SII升高、TyG升高为AMI合并T2DM患者急诊PCI术后MACE的独立危险因素（P＜0.05）。血清BNP、SII、TyG联合预测AMI合并T2DM患者急诊PCI术后MACE的曲线下面积为0.895，大于血清BNP、SII、TyG单独预测的0.758、0.743、0.770。结论：血清BNP、SII、TyG升高会增加AMI合并T2DM患者急诊PCI术后MACE的风险，血清BNP、SII、TyG联合检测对AMI合并T2DM患者急诊PCI术后MACE的预测价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum B-type natriuretic peptide (BNP), systemic immune inflammation index (SII), triglyceride glucose product index (TyG) and major adverse cardiovascular events (MACE) after emergency percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI) combined with type 2 diabetes mellitus (T2DM). Methods: 170 patients with AMI combine with T2DM who underwent emergency PCI in Yidu Central Hospital Affiliate to Shandong Second Medical University from January 2020 to December 2022 were selected, and patients were divided into MACE group and non-MACE group according to whether MACE occurred 1 year after PCI. Serum BNP levels were detected and SII and TyG were calculated. The influencing factors of MACE after emergency PCI in patients with AMI combine with T2DM were analyzed by multivariate Logistic regression, the predictive value of serum BNP, SII and TyG for MACE after emergency PCI in patients with AMI combine with T2DM was analyzed by receiver operating characteristic (ROC) curve. Results: The incidence of MACE in 170 patients with AMI combine with T2DM was 36.47% (62/170) at 1 year after emergency PCI. BNP, SII and TyG in MACE group were higher than those in non-MACE group (P<0.05). KILLIP grade≥II and elevated BNP, elevated SII, and elevated TyG were independent risk factors for MACE after emergency PCI in patients with AMI combine with T2DM (P<0.05). The area under the curve of combined prediction of serum BNP, SII and TyG for MACE after emergency PCI in patients with AMI combine with T2DM was 0.895, which was greater than 0.758, 0.743 and 0.770 predicted by serum BNP, SII and TyG alone. Conclusion: The increase of serum BNP, SII and TyG will increase the risk of MACE after emergency PCI in patients with AMI combined with T2DM, the combine detection of serum BNP, SII and TyG has a high predictive value for MACE after emergency PCI in patients with AMI combine with T2DM. |
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