| 郭建懿,王晓林,郝晓飞,杜 娟,武星光.肺炎支原体肺炎患儿血清总IgE 、CCSP、TIM-3与病情严重程度和预后的关系研究[J].现代生物医学进展英文版,2024,(17):3279-3283. |
| 肺炎支原体肺炎患儿血清总IgE 、CCSP、TIM-3与病情严重程度和预后的关系研究 |
| Study on the Relationship between Serum Total IgE, CCSP, TIM-3, Severity of Disease and Prognosis in Children with Mycoplasma Pneumoniae Pneumonia |
| Received:March 08, 2024 Revised:March 31, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.17.016 |
| 中文关键词: 肺炎支原体肺炎 免疫球蛋白E Clara细胞分泌蛋白 T细胞免疫球蛋白粘蛋白分子3 病情严重程度 预后 |
| 英文关键词: Mycoplasma pneumoniae pneumonia Immunoglobulin E Clara cell secretory protein T cell immunoglobulin mucin molecule 3 Severity of disease Prognosis |
| 基金项目:山西省重点研发计划项目（201803D31163） |
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| 中文摘要: |
| 摘要 目的：探讨肺炎支原体肺炎（MPP）患儿血清总免疫球蛋白E（IgE） 、Clara细胞分泌蛋白（CCSP）、T细胞免疫球蛋白粘蛋白分子3（TIM-3）与病情严重程度和预后的关系。方法：选取2021年8月~2023年8月山西省儿童医院收治的182例MPP患儿为研究对象纳入观察组，根据MPP患儿病情情况分为轻症组和重症组，并根据MPP患儿治疗后的预后情况，分为预后良好组和预后不良组。另选同期体检健康的儿童100例纳入对照组。检测血清总IgE 、CCSP、TIM-3水平，采用单因素和多因素Logistic回归分析MPP患儿发生预后不良的影响因素。结果：观察组血清总IgE、TIM-3高于对照组，CCSP低于对照组（P<0.05）。重症组血清总IgE、TIM-3高于轻症组，CCSP低于轻症组（P<0.05）。182例MPP患儿中有59例出现预后不良，预后不良率为32.42%。预后不良组患儿的血清总IgE、TIM-3高于预后良好组，CCSP低于预后良好组（P<0.05）。单因素分析显示预后不良组的C反应蛋白(CRP）水平、重症比例、发热持续时间、临床肺部感染评分（CPIS）、病程高于预后良好组（P<0.05）。经多因素Logistic回归分析发现，病程长、CPIS评分高、血清总IgE、TIM-3升高，CCSP降低是MPP患儿预后不良的危险因素（P<0.05）。结论：血清总IgE、CCSP、TIM-3在MPP患儿中呈现异常表达，与患儿的病情程度密切相关，血清总IgE、TIM-3上升、CCSP降低及病程长、CPIS评分高为MPP患儿预后不良的危险因素。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum total immunoglobulin E (IgE), Clara cell secretory protein (CCSP), T cell immunoglobulin mucin molecule 3 (TIM-3), severity of disease and prognosis in children with mycoplasma pneumoniae pneumonia (MPP). Methods: 182 children with MPP admitted to Shanxi Children's Hospital from August 2021 to August 2023 were selected as observation group, children were divided into mild group and severe group according to the condition of children with MPP, and children were divided into good prognosis group and poor prognosis group according to the prognosis of children with MPP after treatment. Another 100 healthy children who underwent physical examination during the same period were included in control group. The levels of serum total IgE, CCSP and TIM-3 were detected, the influencing factors of poor prognosis in children with MPP were analyzed by univariate and multivariate Logistic regression analysis. Results: The serum total IgE and TIM-3 in observation group were higher than those in control group, and CCSP was lower than that in control group (P<0.05). The serum total IgE and TIM-3 in severe group were higher than those in mild group, and CCSP was lower than that in mild group (P<0.05). Among the 182 children with MPP, 59 had poor prognosis, with a poor prognosis rate of 32.42%. The serum total IgE and TIM-3 in poor prognosis group were higher than those in good prognosis group, and CCSP was lower than that in good prognosis group (P<0.05). Univariate analysis showed that the level of C-reactive protein (CRP), proportion of severe cases, duration of fever, clinical pulmonary infection score (CPIS) and course of disease in poor prognosis group were higher than those in good prognosis group (P<0.05). Multivariate Logistic regression analysis showed that, long course of disease, high CPIS score, elevated serum total IgE, TIM-3 and decreased CCSP were risk factors for poor prognosis in children with MPP (P<0.05). Conclusion: The abnormal expression of serum total IgE, CCSP and TIM-3 in children with MPP are closely relate to the severity of the disease, the increase of serum total IgE and TIM-3, the decrease of CCSP, the long course of disease and the high CPIS score are risk factors for poor prognosis in children with MPP. |
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