| 魏思雨,刘宇莹,樊丽颖,魏 媞,张家新.非特殊型浸润性乳腺癌组织NUAK1、NUAK2蛋白表达与临床病理特征和预后的关系研究[J].现代生物医学进展英文版,2024,(17):3260-3264. |
| 非特殊型浸润性乳腺癌组织NUAK1、NUAK2蛋白表达与临床病理特征和预后的关系研究 |
| Study on Relationship between the Expression of NUAK1 and NUAK2 Protein and Clinicopathological Features and Prognosis in Non-Specific Invasive Breast Cancer |
| Received:March 28, 2024 Revised:April 23, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.17.012 |
| 中文关键词: 非特殊型浸润性乳腺癌 NUAK1 NUAK2 临床病理特征 预后 |
| 英文关键词: Non-specific invasive breast cancer NUAK1 NUAK Clinicopathological features Prognosis |
| 基金项目:江苏省中医药科技发展计划面上项目（MS2021101）；中国乳腺肿瘤青年学者科研项目（CYBER-2021-010）；徐州市重点研发计划社会发展项目（KC21218）；国家自然科学基金青年基金项目（81602321）；江苏省研究生科研与实践创新计划项目（SJCX22_1266） |
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| 中文摘要: |
| 摘要 目的：探讨非特殊型浸润性乳腺癌（IBC-NST）组织NUAK家族SNF1样激酶1（NUAK1）、NUAK家族SNF1样激酶2（NUAK2）蛋白表达与临床病理特征和预后的关系。方法：选择2018年6月至2020年6月徐州医科大学附属医院收治的132例IBC-NST患者。检测癌组织以及癌旁组织中NUAK2、NUAK1蛋白表达情况，分析癌组织中NUAK2、NUAK1蛋白表达与临床病理特征的关系。IBC-NST患者出院后随访3年，采用Kaplan-Meier 生存曲线分析NUAK1、NUAK2阴性和阳性表达患者生存差异，采用多因素COX回归分析IBC-NST患者预后的影响因素。结果：与癌旁组织相比，IBC-NST癌组织NUAK2、NUAK1蛋白阳性表达率更高（P＜0.05）。IBC-NST癌组织NUAK2、NUAK1蛋白阳性表达率与分化程度、TNM分期、淋巴结转移情况有关（P＜0.05）。NUAK1阳性表达IBC-NST患者3年无进展生存（PFS）率低于NUAK1阴性表达的IBC-NST患者（P＜0.05），NUAK2阳性表达IBC-NST患者3年PFS率低于NUAK2阴性表达的IBC-NST患者（P＜0.05）。IBC-NST患者预后不良的危险因素包括NUAK1阳性表达、淋巴结转移、NUAK2阳性表达（P＜0.05）。结论：IBC-NST癌组织NUAK1、NUAK2蛋白阳性表达率显著增高，NUAK1、NUAK2蛋白阳性表达与分化程度、淋巴结转移、TNM分期、不良预后有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between the expression of NUAK family SNF1-like kinase 1 (NUAK1) and NUAK family SNF1-like kinase 2 (NUAK2) protein and clinicopathological features and prognosis in non-specific invasive breast cancer (IBC-NST). Methods: 132 patients with IBC-NST admitted to the Affiliated Hospital of Xuzhou Medical University from June 2018 to June 2020 were selected. Detected the expression of NUAK2 and NUAK1 proteins in cancer tissue and adjacent tissues, the relationship between the expression of NUAK2, NUAK1 protein in cancer tissues and clinicopathological features were analyzed. IBC-NST patients were followed up for 3 years after discharge, the survival difference between patients with negative and positive expression of NUAK1 and NUAK2 were analyzed by Kaplan-Meier survival curve, the factors affecting the prognosis of IBC-NST patients were analyzed by multivariate COX regression analysis. Results: Compared with adjacent tissues, IBC-NST had a higher positive expression rate of NUAK2 and NUAK1 proteins in cancer tissues (P<0.05). The positive expression rates of NUAK2 and NUAK1 proteins in IBC-NST cancer tissue were related to the degree of differentiation, TNM staging, and lymph node metastasis (P<0.05). The 3-year progression-free survival (PFS) rate in IBC-NST patients with NUAK1 positive expression was lower than that in IBC-NST patients with NUAK1 negative expression (P<0.05), and the 3-year PFS rate in IBC-NST patients with NUAK2 positive expression was lower than that in IBC-NST patients with NUAK2 negative expression (P<0.05). Risk factors for poor prognosis in IBC-NST patients included NUAK1 positive expression, lymph node metastasis, and NUAK2 positive expression (P<0.05). Conclusion: The positive expression rates of NUAK1 and NUAK2 proteins in IBC-NST cancer tissue are significantly increased. The positive expression of NUAK1 and NUAK2 proteins is related to the degree of differentiation, lymph node metastasis, TNM staging, and poor prognosis. |
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