| 石 敏,王 琼,周英旎,李文娟,李晓苗.血清RVE1、CysC、SOCS1水平与桥本甲状腺炎患者炎症反应、甲状腺功能及Th1/Th2细胞因子的关系[J].现代生物医学进展英文版,2024,(17):3241-3245. |
| 血清RVE1、CysC、SOCS1水平与桥本甲状腺炎患者炎症反应、甲状腺功能及Th1/Th2细胞因子的关系 |
| Relationship between Serum RVE1, CysC, SOCS1 Levels and Inflammatory Response, Thyroid Function and Th1/Th2 Cytokines in Patients with Hashimoto's Thyroiditis |
| Received:April 08, 2024 Revised:April 30, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.17.008 |
| 中文关键词: 桥本甲状腺炎 RVE1 CysC SOCS1 炎症反应 甲状腺功能 Th1/Th2细胞因子 |
| 英文关键词: Hashimoto's thyroiditis RVE1 CysC SOCS1 Inflammatory response Thyroid function Th1/Th2 cytokines |
| 基金项目:国家自然科学基金面上项目（81573746） |
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| 中文摘要: |
| 摘要 目的：探讨血清溶解素E1（RVE1）、胱抑素C（CysC）、细胞因子信号传导抑制因子1（SOCS1）水平与桥本甲状腺炎（HT）患者炎症反应、甲状腺功能及Th1/Th2细胞因子的关系。方法：选择2020年7月至2023年10月就诊于空军军医大学第一附属医院的121例HT患者作为HT组，另选同期于我院体检健康的80例体检者作为对照组。对比两组血清RVE1、CysC、SOCS1水平及炎性因子[C反应蛋白（CRP）、红细胞沉降率（ESR）、白细胞介素（IL）-12、IL-23]、甲状腺功能指标[游离三碘甲状腺原氨酸（FT3）、促甲状腺激素（TSH）、游离甲状腺素（FT4）]、Th1/Th2细胞因子[干扰素-γ（IFN-γ）、IL-4、IL-10]水平，Pearson相关性分析血清RVE1、CysC、SOCS1水平与HT患者炎症反应、甲状腺功能、Th1/Th2细胞因子的相关性。结果：与对照组相比，HT组血清RVE1、FT3、FT4、IL-10更低，ESR、CRP、IL-12、IL-23、TSH、CysC、SOCS1、IFN-γ、IL-4水平更高（P＜0.05）。Pearson相关性分析结果发现，HT患者血清ESR、CRP、IL-12、IL-23、TSH、IFN-γ、IL-4水平与RVE1呈负相关（P＜0.05），与CysC、SOCS1呈正相关（P＜0.05）；血清FT3、FT4、IL-10水平与CysC、SOCS1呈负相关，与RVE1呈正相关（P＜0.05）。结论：HT患者血清RVE1水平异常降低、CysC及SOCS1水平异常升高，与炎症反应、甲状腺功能障碍、免疫功能失衡密切相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum lysin E1 (RVE1), cystatin C (CysC), suppressor of cytokine signaling 1 (SOCS1) and inflammatory response, thyroid function and Th1/Th2 cytokines in patients with hashimoto's thyroiditis (HT). Methods: 121 patients with HT who were admitted to The First Affiliated Hospital of Air Force Military Medical University from July 2020 to October 2023 were selected as HT group, and 80 healthy subjects who underwent physical examination in our hospital of Air Force Military Medical University during the same period were selected as control group. The levels of serum RVE1, CysC, SOCS1 and inflammatory factors [C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), interleukin (IL)-12, IL-23], thyroid function indexes [thyroid stimulating hormone (TSH), free triiodothyronine (FT3), free thyroxine (FT4)], Th1/Th2 cytokines [interferon-γ ( IFN-γ ), IL-4, IL-10] were compared between two groups, the correlation between serum RVE1, CysC, SOCS1 levels and inflammatory response, thyroid function, Th1/Th2 cytokines in HT patients were analyzed by Pearson correlation analysis. Results: Compared with the control group, the serum RVE1, FT3, FT4, IL-10 were lower, ESR, CRP, IL-12, IL-23, TSH, CysC, SOCS1, IFN-γ, IL-4 were higher (P<0.05). Pearson correlation analysis showed that, the levels of serum ESR, CRP, IL-12, IL-23, TSH, IFN-γ and IL-4 in HT patients were positively correlated with CysC and SOCS1 (P<0.05), negatively correlated with RVE1 (P<0.05). Serum FT3, FT4 and IL-10 levels were positively correlated with RVE1 (P<0.05), and negatively correlated with CysC and SOCS1 (P<0.05). Conclusion: Ababnormally decreased serum RVE1 levels and CysC and SOCS1 levels in HT patients are closely related to inflammatory response, thyroid dysfunction and immune function imbalance. |
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