| 郭 瑞,黄漫清,崔 颖,陈 景,郑子仁.糖尿病视网膜病变患者血清hs-CRP、CHIT1、midkine与病变严重程度和视力残疾的关系[J].现代生物医学进展英文版,2024,(17):3233-3236. |
| 糖尿病视网膜病变患者血清hs-CRP、CHIT1、midkine与病变严重程度和视力残疾的关系 |
| Relationship between Serum hs-CRP, CHIT1, midkine and Severity of the Disease and Visual Disability in Patients with Diabetic Retinopathy |
| Received:April 08, 2024 Revised:April 30, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.17.006 |
| 中文关键词: 视力残疾 糖尿病视网膜病变 hs-CRP CHIT1 midkine 病变严重程度 |
| 英文关键词: Visual disability Diabetic retinopathy hs-CRP CHIT1 Midkine Severity of the disease |
| 基金项目:广东省医学科学技术研究基金项目（A2016202） |
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| 中文摘要: |
| 摘要 目的：探讨糖尿病视网膜病变（DR）患者血清超敏C反应蛋白（hs-CRP）、几丁质酶1（CHIT1）、中期因子（midkine）与病变严重程度和视力残疾的关系。方法：选取2021年3月-2022年12月期间我院收治的198例2型糖尿病DR患者，根据病变严重程度，分为非增生型DR、增生型DR，例数分别为121例、77例，对比非增生型DR和增生型DR血清hs-CRP、CHIT1、midkine水平。以门诊复查的随访形式随访1年，根据DR患者视力残疾发生情况将患者分为视力残疾组和非视力残疾组，例数分别为31例和167例，对比视力残疾组和非视力残疾组的血清hs-CRP、CHIT1、midkine水平，采用Logistic回归分析视力残疾的危险因素。结果：增生型DR患者血清hs-CRP、CHIT1、midkine水平高于非增生型DR患者（P<0.05）。视力残疾组的血清hs-CRP、CHIT1、midkine水平高于非视力残疾组（P<0.05）。单因素分析结果显示：DR患者视力残疾与性别、年龄、眼压、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、胰岛素抵抗指数（HOMA-IR）无关（P>0.05），与糖尿病病程、DR病程、糖化血红蛋白（HbAlc）有关（P<0.05）。Logistic回归分析显示：糖尿病病程越长、DR病程越长、hs-CRP升高、CHIT1升高、midkine升高是DR患者视力残疾的主要危险因素（P<0.05）。结论：DR患者血清hs-CRP、CHIT1、midkine升高，与病变严重程度有关，同时DR患者视力残疾受到hs-CRP、CHIT1、midkine的影响，值得引起临床重视。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP), chitinase 1 (CHIT1), mid-term factor (midkine) and severity of the disease and visual disability in patients with diabetic retinopathy (DR). Methods: 198 type 2 DR patients admitted to our hospital from March 2021 to December 2022 were selected, according to the severity of the disease, patients were divided into non-proliferative DR and proliferative DR, the number of cases was 121 and 77 cases respectively, the levels of serum hs-CRP, CHIT1 and midkine in non-proliferative DR and proliferative DR were compared. The patients were followed up for 1 year in the form of outpatient review to observe the occurrence of visual disability in DR patients. The patients were divided into visual disability group and non-visual disability group, the number of cases was 31 cases and 167 cases respectively. The levels of serum hs-CRP, CHIT1 and midkine in visual disability group and non-visual disability group were compared, the risk factors of visual disability were analyzed by Logistic regression. Results: The levels of serum hs-CRP, CHIT1 and midkine in patients with proliferative DR were higher than those in patients with non-proliferative DR (P<0.05). The levels of serum hs-CRP, CHIT1 and midkine in visual disability group were higher than those in non-visual disability group (P<0.05). The results of univariate analysis showed that, visual disability in DR patients was not related to gender, age, intraocular pressure, fasting blood glucose (FPG), triglyceride (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and insulin resistance index (HOMA-IR) (P>0.05), but related to the course of diabetes, the course of DR and glycosylated hemoglobin (HbAlc) (P<0.05). Logistic regression analysis showed that, the longer the course of diabetes, the longer the course of DR, the higher hs-CRP, the higher CHIT1 and the higher midkine were the main risk factors for visual disability in DR patients (P<0.05). Conclusion: The increase of serum hs-CRP, CHIT1 and midkine in DR patients are relate to the severity of the disease, and the visual disability of DR patients is affected by hs-CRP, CHIT1 and midkine, which is worthy of clinical attention. |
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