| 丁盼盼,张 庆,王宏健,王 昕,王子成,田杰利.右美托咪定联合超声引导神经阻滞对髋部骨折合并糖尿病患者术后镇痛效果、免疫应激和疼痛介质的影响[J].现代生物医学进展英文版,2024,(16):3176-3180. |
| 右美托咪定联合超声引导神经阻滞对髋部骨折合并糖尿病患者术后镇痛效果、免疫应激和疼痛介质的影响 |
| Effects of Dexmedetomidine Combined with Ultrasound-Guided Nerve Block on Postoperative Analgesia, Immune Stress and Pain Mediators in Patients with Hip Fracture Complicated with Diabetes |
| Received:February 04, 2024 Revised:February 27, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.16.035 |
| 中文关键词: 右美托咪定 超声引导 神经阻滞 髋部骨折 糖尿病 镇痛 免疫应激 疼痛介质 |
| 英文关键词: Dexmedetomidine Ultrasound-guided Nerve block Hip fracture Diabetes Analgesia Immune stress Pain mediators |
| 基金项目:安徽省自然科学基金项目（20210319）；合肥市第二人民医院院级科研基金项目（2021ygkt39）；合肥市卫健委应用医学研究项目（Hwk2021vb009） |
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| 中文摘要: |
| 摘要 目的：观察右美托咪定联合超声引导神经阻滞对髋部骨折合并糖尿病患者术后镇痛效果、免疫应激和疼痛介质的影响。方法：按照随机数字表法将2020年6月-2023年6月期间我院收治的120例髋部骨折合并糖尿病患者分为对照组60例（超声引导神经阻滞）和研究组60例（右美托咪定联合超声引导神经阻滞）。术后两组均行自控静脉镇痛（PCIA）镇痛。对比两组镇静、镇痛情况、PCIA按压次数、免疫功能、应激反应、疼痛介质，同时观察两组治疗期间不良反应发生情况。结果：术后12 h、术后24 h、术后48 h，研究组视觉模拟评分法（VAS）评分低于对照组，Ramsay镇静评分高于对照组（P<0.05）。研究组的PCIA按压次数少于对照组（P<0.05）。术后1 d，研究组CD3++++2（PGE2）、肾上腺素（E）、降钙素基因相关肽（CGRP）、P物质（SP）、CD8+0.05）。结论：联合应用超声引导神经阻滞和右美托咪定于髋部骨折合并糖尿病患者，可发挥良好的镇静、镇痛效果，减轻免疫抑制和术后疼痛。 |
| 英文摘要: |
| ABSTRACT Objective: To observe the effects of dexmedetomidine combined with ultrasound-guided nerve block on postoperative analgesia, immune stress and pain mediators in patients with hip fracture complicated with diabetes. Methods: 120 patients with hip fracture complicated with diabetes who were admitted to our hospital from June 2020 to June 2023 were divided into control group 60 cases (ultrasound-guided nerve block) and study group 60 cases (dexmedetomidine combined with ultrasound-guided nerve block) according to the random number table method. Postoperative patient-controlled intravenous analgesia (PCIA) was performed in both groups. The sedation, analgesia, PCIA pressing times, immune function, stress response and pain mediators were compared between two groups, and the occurrence of adverse reactions during the treatment was observed. Results: 12 h, 24 h and 48 h after operation, the visual analogue scale(VAS) score in study group was lower than that in control group, and the Ramsay sedation score was higher than that in control group (P<0.05). The number of PCIA compressions in study group was less than that in control group (P<0.05). 1 d after operation, CD3+, CD4+, CD4+/CD8+ in study group were higher than those in control group, and cortisol (Cor), norepinephrine (NE), prostaglandin E2 (PGE2), epinephrine (E), calcitonin gene-related peptide (CGRP), substance P (SP) and CD8+ were lower than those in control group (P<0.05). In terms of incidence of adverse reactions, there was no difference observed between the two groups in comparison(P>0.05). Conclusion: Ultrasound-guided nerve block combined with dexmedetomidine in patients with hip fracture and diabetes, which can exert good sedative and analgesic effects, reduce immunosuppression and postoperative pain. |
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