| 刘 亮,肖 勇,王 栋,王 冉,耿良元,邹元杰,刘宏毅.血清VEGF、ATⅡ及NE与垂体瘤恶性程度的相关性及对预后预测价值分析[J].现代生物医学进展英文版,2024,(16):3113-3117. |
| 血清VEGF、ATⅡ及NE与垂体瘤恶性程度的相关性及对预后预测价值分析 |
| The Correlation between Serum VEGF, ATII, and NE Levels and the Malignancy of Pituitary Tumors and their Prognostic Value Analysis |
| Received:February 23, 2024 Revised:March 18, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.16.022 |
| 中文关键词: 血管内皮生长因子 血管紧张素Ⅱ 去甲肾上腺素 垂体瘤 |
| 英文关键词: Vascular endothelial growth factor Angiotensin II Norepinephrine Pituitary adenoma |
| 基金项目:国家自然科学基金青年基金项目（82203637） |
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| 中文摘要: |
| 摘要 目的：探讨血清血管内皮生长因子（VEGF）、血管紧张素Ⅱ（ATⅡ）及去甲肾上腺素（NE）与垂体瘤恶性程度的相关性及对预后预测价值。方法：选取我院2018年1月到2021年1月收治的80例垂体瘤患者作为研究对象，将病理诊断确诊为具有侵袭性的20例恶性垂体瘤患者分为恶性组，将其余60例良性垂体瘤患者分为良性组，另选取同期来我院体检的40名健康者作为对照组。对比三组受检者血清VEGF、ATⅡ及NE表达水平，采用Spearman相关性分析法分析血清VEGF、ATⅡ及NE与垂体瘤恶性程度的相关性。随后对80例垂体瘤患者进行3年随访，发生新的转移灶、复发灶及死亡可认定为预后不良，并依照预后情况将80例垂体瘤患者分为两个亚组，即预后不良组（n=23）及预后良好组（n=57），采用logistics回归模型分析垂体瘤预后独立影响因素。结果：三组受检者血清VEGF、ATⅡ及NE表达水平对比差异显著，恶性组高于良性组与对照组（P＜0.05）；Spearman相关分析结果显示：血清VEGF、ATⅡ及NE与垂体瘤恶性程度呈正相关（P＜0.05）；预后良好组与预后不良组患者性别、年龄、肿瘤大小、合并囊变、压迫视神经情况对比无明显差异（P＞0.05），预后良好组与预后不良组患者侵袭性肿瘤、合并瘤卒中及血清VEGF、ATⅡ、NE水平对比差异显著（P＜0.05）；侵袭性肿瘤、血清VEGF、ATⅡ、NE水平升高为垂体瘤预后不良的独立影响因素（P＜0.05）。结论：VEGF、ATⅡ及NE与垂体瘤恶性程度呈正相关，且侵袭性肿瘤、血清VEGF、ATⅡ、NE水平升高为垂体瘤预后不良的独立影响因素。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the correlation between serum vascular endothelial growth factor (VEGF), angiotensin II (AT II), and norepinephrine (NE) with the malignancy of pituitary tumors and their prognostic value. Methods: 80 patients with pituitary tumors admitted to our hospital from January 2018 to January 2021 were selected as the research subjects. 20 patients diagnosed with invasive malignant pituitary tumors by pathological diagnosis were divided into the malignant group, the remaining 60 patients with benign pituitary tumors were divided into the benign group, and 40 healthy individuals who came to our hospital for physical examination during the same period were selected as the control group. Compare the expression levels of serum VEGF, ATII, and NE among three groups of subjects, and use Spearman correlation analysis to analyze the correlation between serum VEGF, ATII, and NE and the malignancy of pituitary tumors. Subsequently, 80 patients with pituitary tumors were followed up for 3 years. The occurrence of new metastases, relapses, and death was considered as poor prognosis. Based on the prognosis, the 80 patients with pituitary tumors were divided into two subgroups, namely the poor prognosis group (n=23) and the good prognosis group (n=57). Logistic regression models were used to analyze the independent prognostic factors of pituitary tumors. Results: There were significant differences in the expression levels of serum VEGF, ATII, and NE among the three groups of subjects. The malignant group was higher than the benign group and the control group (P<0.05); The Spearman correlation analysis results showed that serum VEGF, ATII, and NE were positively correlated with the malignancy of pituitary tumors(P<0.05); There was no significant difference in gender, age, tumor size, concurrent cystic changes, and optic nerve compression between the group with good prognosis and the group with poor prognosis (P>0.05). However, there was a significant difference in invasive tumors, concurrent tumor stroke, and serum VEGF, ATII, and NE levels between the group with good prognosis and the group with poor prognosis (P<0.05); Invasive tumors, elevated levels of serum VEGF, ATII, and NE are independent influencing factors for poor prognosis of pituitary tumors(P<0.05). Conclusion: VEGF, ATII, and NE are positively correlated with the malignancy of pituitary tumors, and invasive tumors and elevated serum VEGF, ATII, and NE levels are independent influencing factors for poor prognosis of pituitary tumors. In clinical practice, it is necessary to improve treatment measures for patients with invasive tumors and those with elevated serum VEGF, ATII, and NE levels to prevent poor prognosis. |
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