| 李秋敏,刘飞飞,樊阳阳,党 群,袁 峰.三酰甘油、氧化修饰低密度脂蛋白及胎盘生长因子与子痫前期病情进展及其发生流产风险的关系研究[J].现代生物医学进展英文版,2024,(15):2965-2969. |
| 三酰甘油、氧化修饰低密度脂蛋白及胎盘生长因子与子痫前期病情进展及其发生流产风险的关系研究 |
| Three Acyl Glycerin, Oxidized Modified Low Density Lipoprotein and Placental Growth Factor with Preeclampsia Progress and Study the Relationship between the Risk of Spontaneous Abortion |
| Received:January 05, 2024 Revised:January 28, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.15.031 |
| 中文关键词: 子痫前期 三酰甘油 氧化修饰低密度脂蛋白 胎盘生长因子 流产 |
| 英文关键词: Preeclampsia Triacylglycerol Oxidation-modified low-density lipoprotein Placental growth factor Miscarry |
| 基金项目:陕西省重点研发计划项目（2022SF-209） |
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| 中文摘要: |
| 摘要 目的：分析血清三酰甘油（TAG）、氧化修饰低密度脂蛋白（OX-LDL）及胎盘生长因子（PLGF）与子痫前期病情进展及其发生流产风险的关系。方法：选择我院自2022年2月至2023年2月收治的120例子痫前期孕妇（观察组）及120例孕检结果正常的孕妇（对照组）作为研究对象。检测所有孕妇血清TAG、OX-LDL、PLGF表达水平，记录子痫前期病情进展情况，比较病情进展组与病情稳定组血清TAG、OX-LDL、PLGF表达水平及子宫动脉血流动力学指标，使用多因素Logistic回归分析血清TAG、OX-LDL、PLGF与子痫前期病情进展的关系，受试者工作特征曲线（ROC）分析血清TAG、OX-LDL、PLGF对子痫前期孕妇流产的预测效能。结果：观察组血清TAG、OX-LDL高于对照组，PLGF水平低于对照组（P＜0.05）；病情进展组血清TAG、OX-LDL水平均高于病情稳定组，PLGF水平低于病情稳定组（P＜0.05）；经多因素Logistic回归分析，血清TAG、OX-LDL、PLGF均是子痫前期病情进展的独立预测因素（P＜0.05）；病情进展组子宫动脉搏动指数（PI）、阻力指数（RI）、收缩期与舒张期血流速度比值（S/D）均大于病情稳定组，差异显著（P＜0.05）；经Pearson相关性分析，子痫前期孕妇子宫动脉PI、RI、S/D与血清TAG、OX-LDL表达水平呈正相关（P＜0.05），与PLGF水平呈负相关（P＜0.05）；经ROC曲线分析，血清TAG、OX-LDL联合PLGF预测子痫前期孕妇发生流产的AUC为0.908，大于TAG的0.648、OX-LDL的0.660和PLGF的0.673（P＜0.05）。结论：血清TAG、OX-LDL、PLGF与子痫前期病情进展密切相关，联合应用对流产具有一定预测价值，值得临床予以重视应用。 |
| 英文摘要: |
| ABSTRACT Objective: Analysis of serum three acyl glycerin (TAG), oxidized modified low density lipoprotein (OX-LDL) and placental growth factor (PLGF) with preeclampsia disease progression and the relationship between the risk of spontaneous abortion. Methods: A total of 120 pregnant women with preeclampsia (observation group) and 120 pregnant women with normal pregnancy test results (control group) admitted to our hospital from February 2022 to February 2023 were selected as research objects. The expression levels of serum TAG, OX-LDL and PLGF in all pregnant women were detected, and the progress of preeclampsia was recorded. More progress with stable condition group TAG,OX-LDL, serum PLGF expression level indicators and uterine artery blood flow mechanics. Using multiariable Logistic regression analysis of serum TAG, OX-LDL, PLGF and preeclampsia progression, the relationship between the receiver-operating characteristic curve (ROC) analysis of serum TAG, OX-LDL and PLGF to preeclampsia prediction to miscarry. Results: Observation group TAG, OX-LDL is higher than the control group, serum PLGF level lower than the control group, (P<0.05). Progression group serum TAG, OX-LDL level group were higher than in a stable condition and PLGF level under stable condition group (P<0.05). The multi-factor Logistic regression analysis, TAG, OX-LDL, serum PLGF were preeclampsia is an independent predictor of disease progression (P<0.05). Progression group of uterine artery pulsation index (PI), resistance index (RI), systolic and diastolic blood flow velocity ratio (S/D) were greater than in a stable condition group (P<0.05). The Pearson correlation analysis, preeclampsia pregnant uterine artery PI, RI and S/D and serum TAG, OX-LDL expression levels were positively correlated (P<0.05), and negatively correlated to the level of PLGF (P<0.05). According to ROC curve analysis, the AUC of serum TAG, OX-LDL combined with PLGF in predicting abortion of preeclampsia pregnant women was 0.908, which was greater than 0.648 of TAG, 0.660 of OX-LDL and 0.673 of PLGF (P<0.05). Conclusion: Serum TAG, OX-LDL and PLGF are closely related to the progression of preeclampsia. The combined application has a certain predictive value for abortion and is worthy of clinical attention. |
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