| 智冰清,赵秋菊,苏衍进,王惠玲,吕 予,侯杰军.清热利湿健脾降糖方联合司美格鲁肽治疗超重/肥胖型2型糖尿病的效果及对糖脂代谢、胰岛素分泌的影响[J].现代生物医学进展英文版,2024,(15):2934-2938. |
| 清热利湿健脾降糖方联合司美格鲁肽治疗超重/肥胖型2型糖尿病的效果及对糖脂代谢、胰岛素分泌的影响 |
| Effect of Qingre Lishi Jianpi Jiangtang Recipe Combined with Smeglutide in the Treatment of Overweight/Obesity Type 2 Diabetes and Its Effect on Glucose and Lipid Metabolism and Insulin Secretion |
| Received:January 26, 2024 Revised:February 23, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.15.025 |
| 中文关键词: 清热利湿健脾降糖方 司美格鲁肽 超重/肥胖 2型糖尿病 |
| 英文关键词: Qingre Lishi Jianpi Jiangtang Fang Smegglutide Overweight/obesity Type 2 diabetes |
| 基金项目:陕西省重点研发计划项目（2020SF-336） |
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| 中文摘要: |
| 摘要 目的：探讨清热利湿健脾降糖方联合司美格鲁肽对超重/肥胖型2型糖尿病的应用效果。方法：前瞻性选取我院2021年8月~2023年8月来我院检查并治疗的80例超重/肥胖型2型糖尿病患者展开研究，应用抽签法分为对照组（n=30）、联合组1（n=25）与联合组2（n=25）。对照组常规口服二甲双胍，联合组1在对照组基础上增加司美格鲁肽治疗，联合组2在对照组基础上增加清热利湿健脾降糖方联合司美格鲁肽治疗。对比三组患者治疗前后糖代谢、体质量指数与脂代谢水平，胰岛素抵抗相关指数及不良反应发生率。结果：治疗后三组患者餐后2 h血糖、空腹血糖、糖化血红蛋白（HbAlc）、体质量指数（BMI）均降低，且联合组2明显低于联合组1和对照组（P＜0.05）；治疗后三组患者甘油三酯（TG）、总胆固醇（TC）、低密度脂蛋白（LDL-C）均降低，联合组2明显低于联合组1和对照组，高密度脂蛋白（HDL-C）升高，联合组2明显高于联合组1和对照组（P＜0.05）；治疗后三组胰岛素抵抗指数（HOMA-IR）均降低，联合组2明显低于联合组1和对照组，胰岛β细胞功能指数（HOMA-β）升高，联合组2明显高于联合组1和对照组（P＜0.05）；三组患者不良反应发生率对比无明显差异（P＞0.05）。结论：清热利湿健脾降糖方联合司美格鲁肽可降低超重/肥胖型2型糖尿病患者血糖水平，促进糖代谢，降低体质量指数，改善脂代谢水平，同时可进一步改善患者胰岛素抵抗情况，促进胰岛素分泌，且安全性较高。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of Qingre Lishi Jianpi Jiangtang Recipe combined with Smeaglutide in the treatment of overweight/obese type 2 diabetes and its effect on glucose and lipid metabolism and insulin secretion. Methods: We prospectively selected 80 overweight/obese type 2 diabetes patients who were examined and treated in our hospital from August 2021 to August 2023, and divided them into control group (n=30), experimental group 1 (n=25) and experimental group 2 (n=25) by lot drawing. The control group received routine oral administration of metformin. In Experiment 1, treatment with smeglutide was added to the control group, while in Experiment 2, treatment with a combination of Qingre Lishi Jianpi Jiangtang Formula and smeglutide was added to the control group. Compare the levels of glucose metabolism, body mass index, lipid metabolism, insulin resistance related index, and incidence of adverse reactions among three groups of patients before and after treatment. Results: After treatment, 2-hour postprandial blood sugar, fasting blood sugar, glycated haemoglobin (HbAlc) and body mass index (BMI) of the three patient groups decreased, and Joint group 2 was significantly lower than Joint group 1 and control group (P<0.05); After treatment, triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL-C) were reduced in three patient groups. Joint group 2 was significantly lower than Joint group 1 and control group, while high density lipoprotein (HDL-C) increases. Joint group 2 was significantly higher than Joint group 1 and control group (P<0.05); After treatment, the insulin resistance index (HOMA-IR) of all three groups decreased, and Joint group 2 was significantly lower than Joint group 1 and control group, with pancreatic islands β Cellular Function Index (HOMA)- β) increased, Joint group 2 was significantly higher than Joint group 1 and control group (P<0.05); There was no significant difference in the incidence of adverse reactions between the three patient groups (P>0.05). Conclusion: Qingre Lishi Jianpi Jiangtang Recipe combined with Smeglutide can reduce the blood sugar level, promote glucose metabolism, reduce body mass index, improve lipid metabolism in overweight/obese type 2 diabetes patients, and further improve the insulin resistance of patients, promote insulin secretion, with high safety. |
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