| 张 兰,郭玉冰,王 星,董玉婷,王玉珍.古塞奇尤单抗联合消疕汤对寻常型银屑病的治疗效果及对血细胞衍生炎症指标影响[J].现代生物医学进展英文版,2024,(14):2780-2784. |
| 古塞奇尤单抗联合消疕汤对寻常型银屑病的治疗效果及对血细胞衍生炎症指标影响 |
| The Therapeutic Effect of Combination of Guseczumab and Xiaobi Tang on Psoriasis Vulgaris and Its Impact on Blood Cell Derived Inflammatory Markers |
| Received:December 31, 2023 Revised:January 27, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.14.035 |
| 中文关键词: 古塞奇尤单 消疕汤 寻常型银屑病 |
| 英文关键词: Gusaichiudan Xiaobi Tang Psoriasis vulgaris |
| 基金项目:陕西省自然科学基础研究计划项目（2021JM-267） |
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| 中文摘要: |
| 摘要 目的：探讨古塞奇尤单抗联合消疕汤对寻常型银屑病的治疗效果及对血细胞衍生炎症指标影响。方法：选取我院2020年10月到2023年10月收治的86例寻常型银屑病患者，分为观察组与对照组，各组均为43例。对照组采取古塞奇尤单抗治疗，观察组采取古塞奇尤单抗联合消疕汤治疗。对比两组患者临床疗效，治疗前后血细胞衍生炎症指标变化，Th17/treg细胞水平变化以及肝肾功能变化。结果：观察组治疗总有效率明显高于对照组（P＜0.05）；治疗前，两组患者NLPR、dNLR、AISI、SII、SIRI、MLR、PLR、NLR水平对比无差异（P＞0.05），治疗后，均降低，观察组较对照组低（P＜0.05）；治疗前，两组患者Treg、Th17、Th17/Treg对比无差异（P＞0.05），治疗后，两组患者均有差异，且观察组与对照组有差异（P＜0.05）；治疗前两组患者碱性磷酸酶（ALP）、谷丙转氨酶（ALT）、谷草转氨酶（AST）肝功能相关指标及血肌酐（Scr）、尿素氮(BUN)、胱抑素C（CysC）肾功能相关指标表达水平对比无差异（P＞0.05），治疗后两组患者ALP、ALT、AST肝功能相关指标无明显变化，观察组SCr、BUN、CysC肾功能相关指标降低，且观察组低于对照组（P＜0.05）。结论：古塞奇尤单抗联合消疕汤对寻常型银屑病治疗效果显著，且能够减轻机体血细胞衍生炎症指标水平，抑炎反应可能与联合治疗可进一步调节Th17/Treg平衡相关，并且增加消疕汤治疗不对患者肝功能造成明显损伤，可改善肾功能水平。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the therapeutic effect of combination of Gusegzumab and Xiaobi Tang on psoriasis vulgaris and its impact on blood cell derived inflammatory markers. Methods: 86 patients with psoriasis vulgaris admitted to our hospital from October 2020 to October 2023 were selected. They were divided into an observation group and a matched group, with 43 patients in each group. The matched group received treatment with Gusegzumab, while the observation group received treatment with Gusegzumab combined with Xiaobi Tang. Compare the clinical efficacy of two groups of patients, including changes in blood cell derived inflammation indicators, changes in Th17/Treg cell levels, and changes in liver and kidney function before and Post-treatment. Results: The total effective rate of the observation group was higher than that of the matched group(P<0.05); Pretherapy, there was no difference in the levels of NLPR, dNLR, AISI, SII, SIRI, MLR, PLR, and NLR between the two groups of patients(P>0.05). Post-treatment, the levels in both groups of patients decreased. The observation group was lower than the matched group(P<0.05); Pretherapy, there was no difference in Treg, Th17, and Th17/Treg between the two groups of patients(P>0.05). Post-treatment, there were differences between the two groups, and between the observation group and the matched group(P<0.05); There was no difference in the expression levels of liver function related indicators such as alkaline phosphatase(ALP), glutamic pyruvic transaminase(ALT), glutamic oxaloacetic transaminase (AST), blood creatinine (Scr), urea nitrogen (BUN), and cystatin C (CysC), as well as renal function related indicators between the two groups of patients Pretherapy(P>0.05), Post-treatment , there was no change in liver function related indicators such as ALP, ALT, and AST in the two groups of patients. The observation group showed a decrease in renal function related indicators such as SCr, BUN, and CysC, and the observation group was lower than the matched group (P<0.05). Conclusion: The combination of Gusegzumab and Xiaobi Tang has a significant therapeutic effect on psoriasis vulgaris, and can reduce the level of blood cell derived inflammatory indicators in the body. The anti-inflammatory response may be related to the combination therapy further regulating the Th17/Treg balance, and increasing Xiaobi Tang treatment does not cause significant damage to the patient's liver function, which can improve the level of renal function. |
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