| 吴 阳,唐凤英,张 伟,张锋利,高二鹏.血清NLR、PLR、AFP在老年未分化型早期胃癌患者中的预测价值及其临床意义[J].现代生物医学进展英文版,2024,(14):2772-2775. |
| 血清NLR、PLR、AFP在老年未分化型早期胃癌患者中的预测价值及其临床意义 |
| Predictive Value and Clinical Significance of Serum NLR, PLR and AFP in Elderly Patients with Undifferentiated Early Stage Gastric Cancer |
| Received:December 23, 2023 Revised:January 28, 2024 |
| DOI：10.13241/j.cnki.pmb.2024.14.033 |
| 中文关键词: 老年未分化型早期胃癌 血清NLR、PLR、AFP 预测价值 |
| 英文关键词: Undifferentiated early gastric cancer in the elderly Serum AFP, NLR, PLR Forecast value |
| 基金项目:陕西省科技计划项目(2020XKTD-A01) |
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| 中文摘要: |
| 摘要 目的：观察在老年未分化型早期胃癌患者中检测外周血中性粒细胞与淋巴细胞比值（NLR）、血小板淋巴细胞比值（PLR）与血清甲胎蛋白（AFP）的预测价值及其临床意义。方法：纳入80例未分化型早期胃癌患者、80例胃部良性疾病患者、80例体检健康者，将以上患者分为观察组一、观察组二、对照组，均开展血清NLR、PLR、AFP检验，对比三组血清NLR、PLR、AFP水平，评估血清NLR、PLR、AFP对老年未分化型早期胃癌患者病情的预测效果与意义。结果：观察组一、观察组二NLR、PLR、AFP表达量较对照组高，观察组一NLR、PLR、AFP水平高于观察组二（P＜0.05）；有淋巴结转移患者血清NLR、PLR、AFP水平高于无淋巴结转移患者指标水平（P＜0.05）；T1bN0M0患者血清NLR、PLR、AFP水平均分别高于T1aN0M0相应指标水平（P＜0.05）；以胃部良性疾病作为对照，在相关分析下，对胃癌患者血清NLR、PLR、AFP的诊断效果进行分析，血清NLR、PLR、AFP面积分别为0.685、0.755、0.743，敏感度分别达到65%、69%、75%，特异度分别在72%、74%、59%。在血清NLR、PLR、AFP联合检测下，敏感度可以达到72%，特异度达到79%，与单一检测相比血清NLR、PLR、AFP联合检测的特异度较高。结论：针对老年未分化型早期胃癌患者，开展血清NLR、PLR、AFP检测，可以对其病情进行评估与预测，能为临床提供一定的参考依据，存在着较大的临床推广以及应用价值。 |
| 英文摘要: |
| ABSTRACT Objective: The predictive value and clinical significance of peripheral blood neutrophil to lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR) to serum alpha-fetoprotein (AFP) detected in elderly patients with undifferentiated early gastric cancer were observed. Methods: A total of 80 patients with undifferentiated early gastric cancer, 80 patients with benign gastric diseases, and 80 healthy individuals were included. The above patients were divided into experimental group 1, experimental group 2, and control group. Serum AFP, NLR, and PLR tests were carried out, and the three groups were compared. Serum AFP, NLR, and PLR levels were used to evaluate the predictive effect and significance of serum AFP, NLR, and PLR in elderly patients with undifferentiated early gastric cancer. Results: The expression levels of NLR, PLR and AFP in the observation group 1 and observation group 2 were higher than that in the control group(P＜0.05); The levels of serum NLR, PLR and AFP in patients with lymph node metastasis were higher than those in patients without lymph node metastasis(P＜0.05); The levels of serum NLR, PLR and AFP in patients with T1bN0M0 were higher than those in patients with T1aN0M0(P＜0.05); Taking benign gastric diseases as a control, the diagnostic effects of serum NLR, PLR and AFP in patients with gastric cancer were analyzed under correlation analysis. The areas of serum AFP, NLR and PLR were 0.685, 0.755 and 0.743 respectively, with sensitivity of 65%, 69% and 75% respectively, and specificity of 72%, 74% and 59% respectively. Under the combined detection of serum AFP, NLR and PLR, the sensitivity can reach 72% and the specificity can reach 79%. Compared with a single detection, the combined detection of serum AFP, NLR and PLR has a higher specificity. Conclusion: For the elderly patients with undifferentiated early gastric cancer, the detection of serum AFP, NLR, PLR can evaluate and predict their condition, provide a certain reference basis for clinical practice, and have great clinical promotion and application value. |
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