| 王硕英,张小飞,聂 菲,赵侃侃,唐会珍.妊娠期胆汁淤积孕妇血清TBA、ICAM-1及TBIL的表达意义及其对胎儿窘迫的预测价值分析[J].现代生物医学进展英文版,2024,(14):2757-2761. |
| 妊娠期胆汁淤积孕妇血清TBA、ICAM-1及TBIL的表达意义及其对胎儿窘迫的预测价值分析 |
| Expression Significance of Serum TBA, ICAM-1 and TBIL in Pregnant Women with Cholestasis of Pregnancy and Their Predictive Value for Fetal Distress |
| Received:December 08, 2023 Revised:December 31, 2023 |
| DOI：10.13241/j.cnki.pmb.2024.14.030 |
| 中文关键词: 妊娠期胆汁淤积 总胆汁酸 细胞间粘附分子1 总胆红素 胎儿窘迫 |
| 英文关键词: Cholestasis of pregnancy Total bile acid Intercellular adhesion molecule 1 Total bilirubin Fetal distress |
| 基金项目:陕西省重点研发计划项目-社会发展领域（2020SF-001） |
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| 中文摘要: |
| 摘要 目的：分析妊娠期胆汁淤积孕妇血清总胆汁酸（TBA）、细胞间粘附分子1（ICAM-1）及总胆红素（TBIL）的表达意义及其对胎儿窘迫的预测价值。方法：选择我院自2022年3月至2023年10月收治的120例妊娠期胆汁淤积孕妇作为观察组，根据病情严重程度，进一步分为轻度组（72例）和重度组（48例）；另选120例产检正常的孕妇作为对照组。检测所有孕妇血清TBA、ICAM-1及TBIL的表达水平，分析血清TBA、ICAM-1及TBIL与肝功能指标[丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、γ-谷氨酰转肽酶（γ-GT）]的关系，使用受试者工作特征曲线（ROC）分析血清TBA、ICAM-1及TBIL对胎儿窘迫的预测效能。结果：观察组血清TBA、ICAM-1及TBIL的表达水平均高于对照组（P＜0.05）；重度组血清TBA、ICAM-1及TBIL的表达水平均高于轻度组（P＜0.05）；观察组血清ALT、AST、γ-GT的表达水平均高于对照组（P＜0.05）；经Pearson相关性分析，妊娠期胆汁淤积孕妇血清TBA、ICAM-1及TBIL的表达水平与肝功能指标（ALT、AST、γ-GT）均呈正相关（P＜0.05）；经ROC曲线分析，妊娠期胆汁淤积孕妇血清TBA、ICAM-1联合TBIL预测胎儿窘迫发生的敏感度为91.42%、特异度为54.83%，AUC为0.921，大于单项指标的AUC（P＜0.05）。结论：妊娠期胆汁淤积孕妇血清TBA、ICAM-1及TBIL的表达水平均明显升高，与其病情严重程度有关，联合预测胎儿窘迫的效能较好。 |
| 英文摘要: |
| ABSTRACT Objective: To analyze the expression significance of serum total bile acid(TBA), intercellular adhesion molecule-1 (ICAM-1) and total bilirubin (TBIL) in pregnant women with cholestasis of pregnancy and their predictive value for fetal distress. Methods: 120 pregnant women with cholestasis of pregnancy admitted to our hospital from March 2022 to October 2023 were selected as the observation group. According to the severity of the disease, they were further divided into mild group(72 cases) and severe group(48 cases). Another 120 normal pregnant women were selected as control group. The expression levels of serum TBA, ICAM-1 and TBIL were detected in all pregnant women, and the relationship between serum TBA, ICAM-1 and TBIL and liver function indexes (ALT, AST, gamma-glutamyl transpeptidyase) was analyzed. Receiver operating characteristic curve (ROC) was used to analyze the predictive efficacy of serum TBA, ICAM-1 and TBIL in fetal distress. Results: The expression levels of serum TBA,ICAM-1 and TBIL in observation group were higher than those in control group(P<0.05). The expression levels of serum TBA, ICAM-1 and TBIL in severe group were higher than those in mild group (P<0.05). The expression levels of ALT, AST and γ-GT in serum of observation group were higher than those of control group (P<0.05). By Pearson correlation analysis, the expression levels of serum TBA, ICAM-1 and TBIL were positively correlated with liver function indexes (ALT, AST, gamma-GT) in pregnant women with cholestasis of pregnancy (P<0.05). According to ROC curve analysis, the sensitivity of serum TBA, ICAM-1 combined with TBIL in predicting the occurrence of fetal distress in pregnant women with cholestasis of pregnancy was 91.42%, the specificity was 54.83%, and the AUC was 0.921, which was higher than the AUC of single index (P<0.05). Conclusion: The expression levels of serum TBA, ICAM-1 and TBIL in pregnant women with cholestasis of pregnancy are significantly increased, which is related to the severity of the disease, and the combined prediction of fetal distress is better. |
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